Systems and methods for improving electrochemical analyte sensors
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1. A method for identifying an interfering species using an analyte-measuring device, the method comprising:
- providing at least one electrochemical sensor;
measuring a first signal output obtained at a first bias potential setting;
measuring a second signal output obtained at a second bias potential setting;
comparing the first signal output with the second signal output to determine a differential measurement, thereby identifying a presence of an interfering species in a liquid; and
calculating an analyte concentration from the differential measurement, wherein the step of calculating is performed when interfering species are positively identified, and wherein the interfering species are positively identified when the differential measurement is above a set threshold.
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Abstract
An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
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42 Claims
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1. A method for identifying an interfering species using an analyte-measuring device, the method comprising:
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providing at least one electrochemical sensor; measuring a first signal output obtained at a first bias potential setting; measuring a second signal output obtained at a second bias potential setting; comparing the first signal output with the second signal output to determine a differential measurement, thereby identifying a presence of an interfering species in a liquid; and calculating an analyte concentration from the differential measurement, wherein the step of calculating is performed when interfering species are positively identified, and wherein the interfering species are positively identified when the differential measurement is above a set threshold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for identifying an interfering species using an analyte-measuring device, the method comprising:
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providing at least one electrochemical sensor; measuring a first signal output obtained at a first bias potential setting; measuring a second signal output obtained at a second bias potential setting; comparing the first signal output with the second signal output to determine a differential measurement, thereby identifying a presence of an interfering species in a liquid; and deriving an analyte concentration from the first signal output and the second signal output to determine an analyte concentration. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for identifying a signal interference in an analyte-measuring device, the method comprising:
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providing at least one electrochemical sensor; measuring a first signal output obtained at a first bias potential setting; measuring a second signal output at a second bias potential setting; comparing the first signal output with the second signal output to determine a differential measurement, thereby identifying an interference in the signal outputs; and deriving an analyte concentration from the first signal output and the second signal output to determine an analyte concentration. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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Specification