Therapeutic delivery systems
First Claim
1. A targeted therapeutic delivery system comprising gas- or temperature activated gaseous precursor-filled lipid microspheres, wherein said lipid microspheres comprise a therapeutic compound and a negatively charged lipid, and said gas or temperature activated gaseous precursor is selected from the group consisting of perfluorocarbons and sulfur hexafluoride.
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Abstract
Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.
Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
408 Citations
40 Claims
- 1. A targeted therapeutic delivery system comprising gas- or temperature activated gaseous precursor-filled lipid microspheres, wherein said lipid microspheres comprise a therapeutic compound and a negatively charged lipid, and said gas or temperature activated gaseous precursor is selected from the group consisting of perfluorocarbons and sulfur hexafluoride.
Specification