Multiple material dispensing

• US 7,083,590 B1
• Filed: 08/09/2000
• Issued: 08/01/2006
• Est. Priority Date: 08/18/1999
• Status: Expired due to Term

• Current Assignee: Interag
• Original Assignee: Interag
• Inventors: Ogle, Colin Roger, Burggraaf, Shane, Bunt, Craig Robert, Rathbone, Michael John
• Primary Examiner(s): Le, Long V.
• Assistant Examiner(s): Lam, Ann Y.
• Application Number:
  US10/048,981
• Time in Patent Office: 2,183 Days
• Field of Search: 604/143, 604/141, 604/891.1, 604/140, 604/145, 604/890.1, 604/20, 604/21, 604/30, 604/36, 604/38, 604/39, 604/48, 604/151, 604/183, 604/187, 604/208, 604/218, 604/246, 604/264
• US Class Current: 604/30
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61F 6/08 Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception , e.g. combined with devices protecting against contagion
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2210/1475 Vagina
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons

Abstract

A device suitable for use as an intra vaginal device or as a bolus where, after initiation, a member (usually a plunger) moves with a known movement characteristic and is involved in the stagger release of multiple materials. That moving member is used to time the discharge of one or more material from its reservoir in the device (there being separate powering of the timed discharge) or is used to both time and indirectly power the discharge of one or more material from its reservoir, such discharges preferably being in a staggered manner. Optionally the moving member as a plunger may itself also directly discharge a material from a reservoir.

Claims

1. Dispensing apparatus for retention in a body cavity of a target mammal and for dispensing multiple materials in the body cavity, said dispensing apparatus comprising

a housing,

a primary reservoir with a primary outlet from the housing,

a secondary reservoir with a secondary outlet from the housing,

a primary piston,

a secondary piston,

said primary piston being directly contactable with said secondary piston and said primary piston expressing a material in said primary reservoir out of said primary outlet,

said secondary piston expressing a material in the secondary reservoir out of said secondary outlet,

a force generator to act on said primary piston and actuable to cause movement of the primary piston to cause expression of the material in said primary reservoir from the primary outlet,

said movement of said primary piston causing partial expression of the material of the primary reservoir prior to said direct engagement with said secondary piston, and

engagement of said primary piston with said secondary piston causing movement of said secondary piston to cause co-expression of the material in the primary reservoir and the secondary reservoir from the primary outlet and the secondary outlet, respectively.

2. Dispensing apparatus as claimed in claim 1 wherein said force generator is a gas generation unit capable of generating gas which applies pressure to and moves the primary piston.

3. Dispensing apparatus as claimed in claim 2 wherein said gas generation unit is or includes a resistance circuit actuable to generate gas from a battery providing power in the resistance circuit.

4. Dispensing apparatus as claimed in claim 2 wherein a switching mechanism is provided for powering up the gas generation unit.

5. Dispensing apparatus as claimed in claim 1 wherein said gas generation unit includes a hydrogel electrolysed at least in part by a battery powered resistance circuit.

6. Dispensing apparatus of claim 1 further comprising an intravaginal device and the primary material is or includes progesterone.

7. Dispensing apparatus of claim 6 wherein, upon activation of the force generator, progesterone is infused over a period of days into the recipient mammal with expression into the vaginal tract at times during such infusion of at least one of

(i) an oestradiol, and

(ii) a prostaglandin.

8. Dispensing apparatus as claimed in claim 1, wherein said primary reservoir outlet is sealed prior to being opened under action of the primary material as the primary material is pressurised by the primary piston.

9. Dispensing apparatus as claimed in claim 1 wherein said secondary reservoir outlet is sealed prior to being opened under action of the secondary material as the secondary material is pressurised or moved by the secondary piston.

10. Dispensing apparatus capable of retention in a body cavity of a target mammal and for dispensing multiple materials, said dispensing apparatus comprising

an assembly defining, in part, a primary reservoir, a secondary reservoir with an outlet and a second secondary reservoir with an outlet,

a primary piston disposed in said assembly and movable to vary the volume of said primary reservoir,

a second secondary piston for the second secondary reservoir disposed in said assembly and movable to reduce the volume of the second secondary reservoir,

a force generator to act on said primary piston and actuable to cause, in use, after body cavity insertion and in the absence of an external force, a predetermined progressive reduction of the volume of said primary chamber by the primary piston over a period of time,

a liquid or liquid formulation primary material in said primary reservoir expressible via said secondary reservoir outlet under the action of the primary piston, and

a secondary compound, composition or formulation material in the secondary reservoir expressible out of the secondary reservoir outlet under direct or indirect action of the primary piston,

a compound, composition or formulation second secondary material in the second secondary reservoir expressible out of the second secondary reservoir outlet under the action of the second secondary piston,

wherein, in use, without mixing of the materials prior to each egressing from its outlet, said primary piston after sufficient movement causes expression of the secondary material and thereafter a partial expression of the primary material from the primary reservoir, and

wherein said primary piston continues to move and reduce the volume of the primary reservoir whilst both

(2) continuing to express the primary material, and

(3) bearing on the second secondary piston so as to cause the second secondary material to be expressed from the second secondary reservoir outlet under the action of the second secondary piston as that the second secondary piston reduces the volume of the second secondary reservoir.

11. Dispensing apparatus of claim 10, wherein at least one of the secondary reservoir and second secondary reservoir outlets are sealed prior to being opened under either direct or indirect action of the primary piston.

12. Dispensing apparatus of claim 10, wherein said force generator is a gas generation unit capable of generating gas which applies pressure to and moves the primary piston.

13. Dispensing apparatus as claimed in claim 12, wherein a switching mechanism is provided for powering up the gas generation unit.

14. Dispensing apparatus of claim 10, wherein said force generator acts on the primary piston to cause pressurisation of the primary material, and after sufficient time, to cause rupture of a secondary reservoir seal thus causing expression of said secondary material, and

wherein said primary piston continues to move and reduce the volume of the primary reservoir causing expression of said primary material via said secondary reservoir outlet.

15. Dispensing apparatus of claim 10, wherein said secondary reservoir contains a secondary piston, and

wherein said secondary piston is disposed in said secondary reservoir, and

wherein movement of the primary piston under action of the force generator causes the secondary piston to expel into the body cavity thus expressing the secondary material from the secondary reservoir, and

wherein said primary piston continues to move and reduce the volume of the primary reservoir causing expression of said primary material via said secondary reservoir outlet.

16. Dispensing apparatus of claim 10, comprising a plurality of second secondary reservoirs, each with an outlet, each with a second secondary piston and each with a second secondary material.

17. Dispensing apparatus as claimed in claim 16, wherein in each of at least two second secondary reservoirs, there is a different second secondary material.

18. Dispensing apparatus as claimed in claim 17, wherein each of two second secondary reservoirs is adapted to express its second secondary material during expression of the primary material.

19. Dispensing apparatus capable of retention in a body cavity of a target mammal and for dispensing multiple materials, said dispensing apparatus comprising

an assembly defining, in part, a primary reservoir with an outlet and, in part, a secondary reservoir with an outlet,

a primary piston disposed in said assembly and movable to vary the volume of said primary reservoir,

a secondary piston for the secondary reservoir disposed in said assembly and movable to reduce the volume of the secondary reservoir,

a force generator to act on said primary piston and actuable to cause, in use, after body cavity insertion and in the absence of an external force a predetermined progressive reduction of the volume of said primary reservoir by the primary piston over a period of time,

a liquid or liquid formulation primary material in said primary reservoir expressible out of the primary reservoir outlet under the action of the primary piston,

a compound, composition or formulation secondary material in the secondary reservoir expressible out of the secondary reservoir under the action of the secondary piston,

wherein, in use, without mixing of the materials prior to each egressing from its outlet, said primary piston after sufficient movement to provide a partial expression of the primary material from the primary reservoir, continues to move and reduce the volume of the primary reservoir whilst both

(4) continuing to express the primary material, and

(5) bearing on the secondary piston so as to cause secondary material expression from the secondary reservoir outlet under the action of the secondary piston as the secondary piston reduces the volume of the secondary reservoir, and

a plurality of secondary reservoirs, each with an outlet, each with a secondary piston and each with a secondary material.

20. Dispensing apparatus as claimed in claim 19, wherein in each of at least two secondary reservoirs, there is a different secondary material.

21. Dispensing apparatus as claimed in claim 20, wherein each of two secondary reservoirs is adapted to express its secondary material during expression of the primary material.