Mixtures of insulin drug-oligomer comprising polyalkylene glycol
First Claim
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1. A substantially monodispersed mixture of conjugates each comprising human insulin covalently coupled at LysB29 of the human insulin to an oligomer having a formula:
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Abstract
A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.
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Citations
11 Claims
- 1. A substantially monodispersed mixture of conjugates each comprising human insulin covalently coupled at LysB29 of the human insulin to an oligomer having a formula:
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3. A substantially monodispersed mixture of conjugates each comprising an insulin drug coupled to an oligomer having a formula:
- 7. A mixture of conjugates each comprising an insulin drug coupled at LysB29 to an oligomer having a formula:
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10. A mixture of conjugates in which each conjugate:
(a) comprises an insulin drug coupled to an oligomer having a formula;
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11. A substantially monodispersed mixture of conjugates each comprising human insulin covalently coupled at LysB29 of the human insulin to an oligomer having a formula:
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