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Image analysis system and method of biochip

  • US 7,085,404 B2
  • Filed: 10/10/2002
  • Issued: 08/01/2006
  • Est. Priority Date: 10/11/2001
  • Status: Expired due to Fees
First Claim
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1. A biochip image analysis method, comprising:

  • (a) extracting an original image according to a fluorescent base from a biochip comprising a set of specific genes each expressed in a different environment by a fluorescent base of a different color;

    (b) converting the original image into a test image, and extracting an overlapped image and a color image from the test image;

    (c) respectively separating the genes in the spot form from the test image, generating a spot template and a background template including an area within a predetermined distance excluding the spot, detecting an edge for enhancing the luminance of the test image to emphasize the edge for comparing a previously established critical value with a mean value of a predetermined number of pixels from the edge emphasized in the enhancing step, to generate an edge, extracting an effective edge for removing edges under a reference size from the edges detected in the comparing step, and connecting partially opened edges by the shortest distance and storing a template for generating a spot template and a background template comprising the edges extracted in the effective edge extraction step, and storing the spot template and the background template, and(d) outputting statistical data on the basis of the spot template and the background template generated in (b) or (c), and performing luminance correction.

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