Device having a flow channel containing a layer of wicking material

• US 7,086,277 B2
• Filed: 02/23/2004
• Issued: 08/08/2006
• Est. Priority Date: 02/23/2004
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Bailey, Scott L., Karinka, Shridhara Alva, Tess, Mark E.
• Primary Examiner(s): LARKIN, DANIEL SEAN
• Application Number:
  US10/784,764
• Publication Number:
  US 20050183494A1
• Time in Patent Office: 897 Days
• Field of Search: 73/530.1, 73/614.1, 204/403.1, 204/403.14, 422/55, 422/56, 422/57, 422/58, 422/82.01, 422/82.02, 422/82.03
• US Class Current: 73/53.01
• CPC Class Codes: C12Q 1/004 mediator-assisted

Abstract

A device having a flow channel, wherein a layer of mesh is adhered to a surface forming a wall of a flow channel, but the layer of mesh is of such dimensions that the layer of mesh does not contact those portions of the device where electrochemical reactions occur and electrons flow. In one aspect, the invention provides a sensor, such as, for example, a biosensor, in the form of a strip, the sensor being suitable for electrochemical or optical measurement. The sensor comprises a base layer and a cover layer having a layer of mesh adhered thereto, and the base layer is separated from the cover layer by a spacer layer. The base layer, the cover layer having a layer of mesh adhered thereto, and the spacer layer define a flow channel into which a liquid sample is drawn therein and flows therethrough by means of wicking.

Claims

1. A sensor strip comprising:

(a) a base layer having a first major surface and a second major surface;

(b) a cover layer having a first major surface and a second major surface, the first major surface of said cover layer facing the first major surface of said base layer, the first major surface of the cover layer having a layer of mesh adhered thereto;

(c) a spacer layer interposed between the first major surface of said cover layer and the first major surface of said base layer to separate said cover layer from said base layer;

(d) a flow channel having walls formed by said first major surface of said cover layer, said first major surface of said base layer, and said spacer layer, said flow channel having a reaction site therein, the layer of mesh not contacting the reaction site;

(e) a sample application zone, where a liquid sample is introduced into said flow channel; and

(f) at least one opening communicating with said flow channel to allow gas to be vented from said flow channel.

2. The sensor strip of claim 1, wherein said reaction site includes an electrode arrangement.

3. The sensor strip of claim 2, wherein said electrode arrangement comprises a working electrode and a dual-purpose reference electrode/counter electrode.

4. The sensor strip of claim 3, wherein said electrode arrangement further includes a trigger electrode.

5. The sensor strip of claim 3, wherein said electrode arrangement further includes a reagent system on at least said working electrode.

6. The sensor strip of claim 5, wherein said reagent system comprises an enzyme and a mediator for said enzyme.

7. The sensor strip of claim 2, wherein said electrode arrangement comprises a working electrode, a counter electrode, and a reference electrode.

8. The sensor strip of claim 7, wherein said electrode arrangement further includes a trigger electrode.

9. The sensor strip of claim 7, wherein said electrode arrangement further includes a reagent system on at least said working electrode.

10. The sensor strip of claim 9, wherein said reagent system comprises an enzyme and a mediator for said enzyme.

11. The sensor strip of claim 1, wherein said at least one opening is formed in said spacer layer.

12. The sensor strip of claim 1, wherein said at least one opening is formed in said cover layer.

13. The sensor strip of claim 1, wherein said spacer layer comprises a layer of adhesive.

14. The sensor strip of claim 1, wherein said spacer layer comprises a backing having a layer of adhesive on both major surfaces thereof.

15. A sensor strip comprising:

(a) a base layer having a first major surface and a second major surface;

(b) a cover layer having a first major surface and a second major surface, the first major surface of said cover layer facing the first major surface of said base layer, the first major surface of the cover layer having a layer of mesh adhered thereto;

(c) a spacer layer interposed between the first major surface of said cover layer and the first major surface of said base layer to separate said cover layer from said base layer wherein said spacer layer comprises a layer of adhesive, wherein said adhesive is formed from a radiation-curable adhesive;

(d) a flow channel having walls formed by said first major surface of said cover layer, said first major surface of said base layer, and said spacer layer, said flow channel having a reaction site therein, the layer of mesh not contacting the reaction site;

(e) a sample application zone, where a liquid sample is introduced into said flow channel; and

(f) at least one opening communicating with said flow channel to allow gas to be vented from said flow channel.

16. A sensor strip comprising:

(a) a base layer having a first major surface and a second major surface;

(b) a cover layer having a first major surface and a second major surface, the first major surface of said cover layer facing the first major surface of said base layer, the first major surface of the cover layer having a layer of mesh adhered thereto;

(c) a spacer layer interposed between the first major surface of said cover layer and the first major surface of said base layer to separate said cover layer from said base layer wherein said spacer layer comprises a layer of adhesive, wherein said adhesive is formed from a water-borne adhesive or a solvent-borne adhesive;

(d) a flow channel having walls formed by said first major surface of said cover layer, said first major surface of said base layer, and said spacer layer, said flow channel having a reaction site therein, the layer of mesh not contacting the reaction site;

(e) a sample application zone, where a liquid sample is introduced into said flow channel; and

(f) at least one opening communicating with said flow channel to allow gas to be vented from said flow channel.