Biosensor
First Claim
Patent Images
1. A biosensor comprising the following elements:
- (a) first and second plasma-polymerized membranes, wherein said first plasma-polymerized membrane is an acetonitrile plasma polymerized membrane,(b) a catalytic substance immobilized on the first plasma-polymerized membrane, and,(c) a metal electrode pattern in contact with a test sample only via the first plasma-polymerized membrane, wherein said metal electrode pattern is in direct contact with the first and second plasma-polymerized membranes, such that the first plasma-polymerized membrane is above and the second plasma-polymerized membrane is below the metal electrode pattern, said second plasma-polymerized membrane being formed from an organic silicon compound.
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Abstract
A novel biosensor was accomplished using a plasma-polymerized membrane. The biosensor of the present invention is a high-performance biosensor produced by a simpler method and applicable to a wide range of fields.
138 Citations
17 Claims
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1. A biosensor comprising the following elements:
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(a) first and second plasma-polymerized membranes, wherein said first plasma-polymerized membrane is an acetonitrile plasma polymerized membrane, (b) a catalytic substance immobilized on the first plasma-polymerized membrane, and, (c) a metal electrode pattern in contact with a test sample only via the first plasma-polymerized membrane, wherein said metal electrode pattern is in direct contact with the first and second plasma-polymerized membranes, such that the first plasma-polymerized membrane is above and the second plasma-polymerized membrane is below the metal electrode pattern, said second plasma-polymerized membrane being formed from an organic silicon compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for measuring a substrate in a test sample using a biosensor, wherein the biosensor comprises (i) a metal electrode pattern that contacts a test sample only via a plasma-polymerized membrane, wherein the metal electrode pattern is in direct contact with first and second plasma-polymerized membranes, wherein said first plasma polymerized membrane is an acetonitrile plasma polymerized membrane and said second plasma-polymerized membrane is formed from an organic silicon compound, and (ii) a catalytic substance immobilized on the first plasma-polymerized membrane, and wherein said method comprises the following steps of:
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(a) contacting the test sample with the biosensor, and, (b) detecting electrical changes that occur as a result of the reaction between the catalytic substance and substrate using the metal electrode patterns; (c) measuring the substrate based on the electrical charges.
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11. A biosensor comprising:
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a. first and second plasma-polymerized membranes, wherein said first plasma-polymerized membrane is an acetonitrile plasma polymerized membrane; b. a catalytic substance immobilized on the first plasma-polymerized membrane; and
,c. a metal electrode pattern in direct contact with the first and second plasma-polymerized membranes, such that the first plasma-polymerized membrane is above and the second plasma-polymerized membrane is below the metal electrode pattern;
wherein the first plasma-polymerized membrane covers the metal electrode pattern, preventing a specimen from directly contacting the metal electrode pattern and said second plasma-polymerized membrane is formed from an organic silicon compound.
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12. A biosensor comprising:
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a. first and second plasma-polymerized membrane, wherein said first plasma-polymerized membrane is an acetonitrile plasma polymerized membrane; b. a catalytic substance immobilized on the first plasma-polymerized membrane; and
,c. a metal electrode pattern in direct contact the first and second plasma-polymerized membranes, such that the first plasma-polymerized membrane is above and the second plasma-polymerized membrane is below the metal electrode pattern, said second plasma-polymerized membrane being formed from an organic silicon compound; wherein the first plasma-polymerized membrane covers a surface of a board containing the metal electrode pattern, preventing a specimen from directly contacting the metal electrode pattern.
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13. A biosensor comprising:
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a. first and second plasma-polymerized membrane, wherein said first plasma-polymerized membrane is an acetonitrile plasma polymerized membrane; b. a catalytic substance immobilized on the first plasma-polymerized membrane; c. a metal electrode pattern in direct contact with the first and second plasma-polymerized membranes, such that the first plasma-polymerized membrane is above and the second plasma-polymerized membrane is below the metal electrode pattern, said second plasma-polymerized membrane being formed from an organic silicon compound; and d. a structure for containing a specimen; wherein the first plasma-polymerized membrane is interposed between the structure and the metal electrode pattern and prevents a specimen from directly contacting the metal electrode pattern. - View Dependent Claims (14)
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15. A method of manufacturing a biosensor, the method comprising:
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forming a metal electrode pattern layer; depositing a first plasma-polymerized membrane layer over said metal electrode pattern layer so as to cover all exposed portions of said metal electrode pattern layer, wherein said first plasma-polymerized membrane is an acetonitrile plasma polymerized membrane; depositing a second plasma-polymerized membrane layer over said metal electrode pattern layer such that the first plasma-polymerized membrane is above and the second plasma-polymerized membrane is below the metal electrode pattern said second plasma-polymerized membrane being formed from an organic silicon compound; immobilizing a catalytic substance on the first plasma-polymerized membrane layer. - View Dependent Claims (16, 17)
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Specification