Pharmaceutical coating composition and method of use

• US 7,087,243 B2
• Filed: 07/23/2004
• Issued: 08/08/2006
• Est. Priority Date: 09/09/1997
• Status: Expired due to Fees

• Current Assignee: Encinal Pharmaceutical Investments, LLC
• Original Assignee: David E. Edgren, Gurdish Bhatti, Liang-Chang Dong, Patrick S.-L. Wong, Shu Li, Si-Hong Yum
• Inventors: Li, Shu, Edgren, David E., Wong, Patrick S.-L., Dong, Liang-Chang, Bhatti, Gurdish, Yum, Si-Hong
• Primary Examiner(s): TRAN, SUSAN T
• Application Number:
  US10/897,669
• Publication Number:
  US 20050003006A1
• Time in Patent Office: 746 Days
• Field of Search: 427/214, 427/215, 424/480, 424/464
• US Class Current: 424/464
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/282 Organic compounds, e.g. fats
• CPC Class Codes: A61K 9/284 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/2853 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.

Claims

1. A method for fabricating a dosage form, the method comprising:

providing a compressed core comprising a drug;

providing a membrane forming composition comprising a polymer selected from the group consisting of cellulose ester, cellulose ether, and cellulose ester-ether polymers, an amphiphilic triblock copolymer surfactant consists of ethylene oxide-propylene oxide-ethylene oxide, and a single solvent consists of acetone; and

forming a membrane over the core with the membrane forming composition.

2. The method of claim 1, further comprising forming an exit orifice through the membrane fonned over the core.

3. The method of claim 1, wherein providing a compressed core comprises providing a bi-layer core including a drug layer and a push layer.

4. The method of claim 1, wherein providing a membrane forming composition comprises providing a composition formulated to provide a dry coated membrane that includes from about 40 wt % to about 99.5 wt % polymer and from about 0.5 wt % to about 60 wt % amphiphilic triblock copolymer surfactant.