Safe and effective biofilm inhibitory compounds and health-related uses thereof

• US 7,087,661 B1
• Filed: 09/23/1999
• Issued: 08/08/2006
• Est. Priority Date: 09/23/1998
• Status: Expired due to Fees

• Current Assignee: Cernofina, LLC
• Original Assignee: Cernofina, LLC
• Inventors: Zimmerman, Richard C., Alberte, Randall S.
• Primary Examiner(s): YAMNITZKY, MARIE ROSE
• Application Number:
  US09/405,269
• Time in Patent Office: 2,511 Days
• Field of Search: 424/422, 428/411.1, 428/704, 428/543, 427/2.12, 427/2.24, 427/2.28, 427/2.29, 427/2.3, 427/2.31, 558/20, 558/37, 558/38
• US Class Current: 523/122
• CPC Class Codes: A01N 41/02 containing a sulfur-to-oxygen double bond
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/255 of sulfoxy acids or sulfur analogues thereof
• CPC Class Codes: A61L 17/005 containing a biologically active substance, e.g. a medicament or a biocide
• CPC Class Codes: A61L 2300/216 with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 33/0041 characterised by the choice of an antithrombatic agent other than heparin heparinoïd A61L33/08; polypeptides A61L33/12
• CPC Class Codes: A61P 15/18 Feminine contraceptives
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: C07C 305/26 : Halogenosulfates, i.e. monoesters of halogenosulfuric acids
• CPC Class Codes: C09D 5/1625 : organic
• CPC Class Codes: Y10S 428/907 : Resistant against plant or animal attack
• CPC Class Codes: Y10S 47/11 : The application of protective coatings to plants
• CPC Class Codes: Y10T 428/2982 : Particulate matter [e.g., sphere, flake, etc.]
• CPC Class Codes: Y10T 428/2984 : Microcapsule with fluid core [includes liposome]
• CPC Class Codes: Y10T 428/2989 : Microcapsule with solid core [includes liposome]

Abstract

The present invention provides compounds and materials that reduce the accumulation of microorganisms a surface, by interfering with the attachment of the organisms to the surface. The compounds and materials are thus useful in preventing the formation of biofilms on surfaces in health-related environments. By preventing the formation of biofilms, the compounds formulated according to the present invention can be used in the fabrication of grafts, implants, medical devices in order to prevent infection thereof. The compounds formulated according to the present invention display an additional anticoagulant property, permitting their use in settings where decrease in blood coagulability is desirable.

Claims

1. A coating comprising an effective amount of a compound represented by general structure 1:

2. The coating of claim 1, wherein X represents —

OH or Cl.

3. The coating of claim 1, wherein the coating is temporary.

4. The coating of claim 1, wherein the release rate of the compound from the surface is in the range of about 1 to about 200 μ

gcm²d<sup>−

1</sup>.

5. The coating of claim 1, wherein the release of the compound is a sustained release.

6. The coating of claim 1, wherein the coating is formulated as a composition selected from the group consisting of paste, gel, liquid, wax, caulk, adhesive, and paint.

7. The coating of claim 1, wherein the coating is employed as an agent selected from the group consisting of glue, cement and adhesive.