Nucleotides and analogs having photoremovable protecting groups
First Claim
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1. A compound having a photoremovable protecting group covalently attached to a C-3′
- or C-5′
oxygen atom, wherein said compound is selected from the group consisting of a natural or unnatural nucleoside or a natural or unnatural nucleoside having an activated phosphorus group.
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Abstract
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
239 Citations
17 Claims
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1. A compound having a photoremovable protecting group covalently attached to a C-3′
- or C-5′
oxygen atom, wherein said compound is selected from the group consisting of a natural or unnatural nucleoside or a natural or unnatural nucleoside having an activated phosphorus group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- or C-5′
Specification