Predicting susceptibility to neurological dysfunction based on measured neural electrophysiology
First Claim
1. A system for actively measuring at least one electrophysiological parameter of a region of a patient'"'"'s brain and perform an action in response thereto, wherein the electrophysiological parameter comprises an excitability threshold of a neural pathway, the system comprising:
- a stimulation subsystem operative to apply an electrical stimulation signal to the region of the patient'"'"'s brain;
a sensing subsystem operative to detect an evoked response to the electrical stimulation signal;
a processor operative to calculate the electrophysiological parameter based on the evoked response and to initiate an action in response to the calculated electrophysiological parameter; and
a control module including the stimulation subsystem, the sensing subsystem, and the processor, wherein the control module has a biocompatible housing.
3 Assignments
0 Petitions
Accused Products
Abstract
A system and method for determining and predicting a patient'"'"'s susceptibility to neurological dysfunction based on measured electrophysiological parameters employs a self-contained implantable device with depth electrodes implanted in desired locations in the patient'"'"'s brain. The patient'"'"'s neurological tissue is stimulated to determine excitability and refractoriness (or inhibition period) parameters, which are employed to identify susceptibility to abnormal neurological activity, particularly epileptic seizures.
-
Citations
17 Claims
-
1. A system for actively measuring at least one electrophysiological parameter of a region of a patient'"'"'s brain and perform an action in response thereto, wherein the electrophysiological parameter comprises an excitability threshold of a neural pathway, the system comprising:
-
a stimulation subsystem operative to apply an electrical stimulation signal to the region of the patient'"'"'s brain; a sensing subsystem operative to detect an evoked response to the electrical stimulation signal; a processor operative to calculate the electrophysiological parameter based on the evoked response and to initiate an action in response to the calculated electrophysiological parameter; and a control module including the stimulation subsystem, the sensing subsystem, and the processor, wherein the control module has a biocompatible housing. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
-
8. A method for actively measuring an electrophysiological parameter of a region of a patient'"'"'s brain, wherein the electrophysiological parameter comprises an excitability threshold of a neural pathway, the method comprising the steps of;
-
selecting a test value for the electrophysiological parameter; performing a measurement using the test value of the electrophysiological parameter to receive a response; and determining whether the response meets a criterion, and if not, adjusting the test value and repeating the testing and determining steps. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17)
-
Specification