Method and apparatus for filtering and drying a product

• US 7,089,681 B2
• Filed: 11/26/2002
• Issued: 08/15/2006
• Est. Priority Date: 11/26/2002
• Status: Expired due to Fees

• Current Assignee: Alkermes Controlled Therapeutics Inc. II (Alkermes plc)
• Original Assignee: Alkermes Controlled Therapeutics Inc. II (Alkermes plc)
• Inventors: Bissonnette, Douglas M., Troiano, Gregory C., Herbert, Paul F.
• Primary Examiner(s): Smith, Duane
• Assistant Examiner(s): PHAM, MINH CHAU THI
• Application Number:
  US10/304,058
• Publication Number:
  US 20040099612A1
• Time in Patent Office: 1,358 Days
• Field of Search: 210/406, 210/181, 210/184, 210/175, 210/767, 210/774, 345/40, 345/89, 341/65, 341/68, 341/77, 34/92, 342/02, 342/82, 118/723, 95/74, 426/384, 62440-446
• US Class Current: 34/92
• CPC Class Codes: A61K 9/1694 resulting in granules or microspheres of the matrix type containing more than 5% of excipient
• CPC Class Codes: B01D 29/15 arranged for inward flow filtration
• CPC Class Codes: B01D 29/23 arranged for outward flow filtration
• CPC Class Codes: B01D 29/54 arranged concentrically or coaxially
• CPC Class Codes: B01D 35/18 Heating or cooling the filters
• CPC Class Codes: F26B 5/04 by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum F26B11/049 and F26B17/128 take precedence
• CPC Class Codes: F26B 5/06 the process involving freezing

Abstract

The present invention relates to a method and apparatus for filtering and drying a product. In a preferred embodiment, the apparatus comprises a container having a plurality of porous walls and a plurality of solid walls that divide the container into a plurality of product chambers, a plurality of vacuum chambers, and, preferably, a plurality of heat transfer chambers. Each product chamber shares at least one porous wall with an adjacent vacuum chamber. Each product chamber preferably shares at least one solid wall with an adjacent heat transfer chamber. According to the method of the present invention, a product is introduced into the product chambers, where the product is held while a substance is filtered from the product through the porous walls and the product is dried by reducing the pressure in the vacuum chambers and the product chambers. In a preferred embodiment of the method, a heat transfer fluid flows through the heat transfer chambers to facilitate keeping the product frozen and/or to facilitate faster drying of the product.

Claims

1. An apparatus for filtering and drying a product, the apparatus comprising:

a first product chamber;

a vacuum chamber;

a first porous wall that at least partially defines the first product chamber and that at least partially defines the vacuum chamber;

wherein the first product chamber is configured to hold the product for filtering through the first porous wall;

further comprising a heat transfer chamber coupled to the first product chamber;

further comprising a first solid wall at least partially defining the heat transfer chamber and at least partially defining the first product chamber; and

wherein the distance between the first solid wall and the first porous wall is at most five inches.

2. The apparatus of claim 1, wherein the distance between the first solid wall and the first porous wall is at most one inch.

3. The apparatus of claim 1, wherein the first porous wall and the first solid wall are substantially concentric.

4. The apparatus of claim 3, wherein the distance between the first porous wall and the first solid wall is at most one inch.

5. An apparatus for filtering and drying a product, the apparatus comprising:

a first product chamber;

a vacuum chamber;

a first porous wall that at least partially defines the first product chamber and that at least partially defines the vacuum chamber;

wherein the first product chamber is configured to hold the product for filtering through the first porous wall;

further comprising a second product chamber; and

a second porous wall that at least partially defines the vacuum chamber and that at least partially defines the second product chamber.

6. An apparatus for drying and filtering a product, the apparatus comprising:

a container comprising a plurality of porous walls and a plurality of solid walls separating the container into a plurality of product chambers, a plurality of vacuum chambers, and a plurality of heat transfer chambers;

wherein each of the plurality of product chambers shares at least one of the plurality of porous walls with at least one of the plurality of vacuum chambers and each of the plurality of product chambers shares at least one of the plurality of solid walls with at least one of the plurality of heat transfer chambers.

7. The apparatus of claim 6, wherein:

each wall separating one of the plurality of vacuum chambers and one of the plurality of product chambers is one of the plurality of porous walls;

each wall separating one of the plurality of product chambers and one of the plurality of heat transfer chambers is one of the plurality of solid walls; and

,

each wall separating one of the plurality of heat transfer chambers and one of the plurality of vacuum chambers is one of the plurality of solid walls.

8. The apparatus of claim 6, further comprising a vacuum pump coupled to each of the plurality of vacuum chambers for reducing the pressure in the plurality of vacuum chambers.

9. The apparatus of claim 8, further comprising a condenser coupled to each of the plurality of vacuum chambers and to the vacuum pump.

10. The apparatus of claim 6, further comprising a control valve coupled to the plurality vacuum chambers for streaming fluid into the plurality of vacuum chambers.

11. The apparatus of claim 10, further comprising:

a pressure transmitter coupled to the container; and

,

a programmed logic controller coupled to the pressure transmitter and to the control valve;

wherein the programmed logic controller controls the amount of fluid that streams through the control valve responsive to the pressure in the container.

12. The apparatus of claim 6, further comprising a heat transfer inlet coupled to the plurality of heat transfer chambers and a heat transfer outlet coupled to the plurality of heat transfer chambers.

13. The apparatus of claim 6, wherein each of the plurality of heat transfer chambers has a solid top and a solid bottom.

14. The apparatus of claim 6, wherein each of the plurality of product chambers has an open top and a solid bottom.

15. The apparatus of claim 6, wherein each of the plurality of vacuum chambers has a solid top and an open bottom.

16. The apparatus of claim 6, wherein the plurality of porous walls and the plurality of solid walls are substantially concentric.

17. The apparatus of claim 16, wherein the innermost wall is one of the plurality of solid walls and surrounds one of the plurality of heat transfer chambers.

18. The apparatus of claim 17, wherein the walls, other than the innermost wall, are arranged in alternating pairs of the plurality of porous walls and pairs of the plurality of solid walls, and wherein the innermost wall is adjacent to a porous wall.

19. The apparatus of claim 6, wherein every second chamber is one of the plurality of product chambers, every fourth chamber is one of the plurality of vacuum chambers, and all other chambers are heat transfer chambers.

20. The apparatus of claim 19, wherein one of the heat transfer chambers is the innermost chamber.

21. The apparatus of claim 19, wherein one of the vacuum chambers is the innermost chamber.

22. The apparatus of claim 6, wherein every third chamber is a product chamber, every third chamber is a heat transfer chamber, and every third chamber is a vacuum chamber.

23. The apparatus of claim 22, wherein one of the heat transfer chambers is the innermost chamber.

24. The apparatus of claim 22, wherein one of the vacuum chambers is the innermost chamber.

25. The apparatus of claim 6, wherein each of the plurality of product chambers, each of the plurality of vacuum chambers and each of the plurality of heat transfer chambers has a rectangular cross-section.

26. The apparatus of claim 6, wherein all of the plurality of porous walls are parallel to all of the plurality of solid walls.

27. The apparatus of claim 6, wherein the plurality of porous walls and the plurality of solid walls are arranged in a grid defining one or more rows of chambers.

28. The apparatus of claim 27, wherein in every other row of chambers, the chambers alternate between one of the plurality of heat transfer chambers and one of the plurality of product chambers.

29. The apparatus of claim 27, wherein in every other row of chambers, the chambers alternate between one of the plurality of product chambers and one of the plurality of vacuum chambers.

30. The apparatus of claim 6, wherein each of the plurality of product chambers has a width of less than five inches.

31. The apparatus of claim 6, wherein each of the plurality of product chambers has a width of less than one inch.

32. The apparatus of claim 6, further comprising a flange coupled to a top of the container for guiding the delivery of the product into the product chambers.

33. The apparatus of claim 32, further comprising a spout coupled to the flange for facilitating spraying the product into the product chambers.

34. The apparatus of claim 33, wherein the spout comprises a vent.

35. The apparatus of claim 6, wherein each porous wall comprises a material having a pore size that is smaller than a particle size of nearly all of the product.

36. The apparatus of claim 35, wherein the material comprises sintered stainless steel.

37. The apparatus of claim 35, wherein the material comprises ceramic.

38. The apparatus of claim 35, wherein the material comprises plastic.

39. The apparatus of claim 35, wherein the material comprises screen laminate.

40. The apparatus of claim 35, wherein the pore size is no greater than 20 μ

m.

41. An apparatus for filtering and drying a product, the apparatus comprising:

a container comprising a plurality of substantially concentric walls dividing the container into a plurality of chambers, wherein each chamber and each wall surrounding that chamber is assigned a number from 1 to n, counting consecutively from the innermost chamber and innermost wall to the outermost chamber and outermost wall, wherein

if (n+3)/4 is a whole number then the wall with that number is a solid wall and the chamber surrounded by that wall is a heat transfer chamber;

if (n+2)/4 is a whole number then the wall with that number is a porous wall and the chamber surrounded by that wall is a product chamber;

if (n+1)/4 is a whole number, then the wall with that number is a porous wall and the chamber surrounded by that wall is a vacuum chamber;

if n/4 is a whole number, then the wall with that number is a solid wall and the chamber surrounded by that wall is a product chamber.

42. The apparatus of claim 41, wherein n=9.

43. The apparatus of claim 41, wherein (n−

1) is a multiple of 4.

50. The apparatus of claim 43, wherein every point in the product chamber is no more than one inch from a point on the heat transfer source and no more than one inch from a point on the vacuum source.

44. An apparatus for filtering and drying a product, the apparatus comprising:

a container comprising a plurality of substantially concentric walls dividing the container into a plurality of chambers, wherein each chamber and each wall surrounding that chamber is assigned a number from 1 to n, counting consecutively from the innermost chamber and innermost wall to the outermost chamber and outermost wall, wherein

if (n+3)/4 is a whole number, then the wall with that number is a porous wall and the chamber surrounded by that wall is a vacuum chamber;

if (n+2)/4 is a whole number then the wall with that number is a solid wall and the chamber surrounded by that wall is a product chamber;

if (n+1)/4 is a whole number then the wall with that number is a solid wall and the chamber surrounded by that wall is a heat transfer chamber;

if n/4 is a whole number, then the wall with that number is a porous wall and the chamber surrounded by that wall is a product chamber.

45. The apparatus of claim 44, wherein n=11.

46. The apparatus of claim 44, wherein (n−

3) is a multiple of 4.

47. An apparatus for filtering and drying a product, the apparatus comprising:

a container comprising a plurality of substantially concentric walls dividing the container into a plurality of chambers, wherein each chamber and each wall surrounding that chamber is assigned a number from 1 to n, counting consecutively from the innermost chamber and innermost wall to the outermost chamber and outermost wall, wherein

if (n+2)/3 is a whole number, then the wall with that number is a solid wall and the chamber surrounded by that wall is a heat transfer chamber;

if (n+1)/3 is a whole number then the wall with that number is a porous wall and the chamber surrounded by that wall is a product chamber;

if n/3 is a whole number then the wall with that number is a solid wall and the chamber surrounded by that wall is a vacuum chamber.

48. The apparatus of claim 47, wherein n=9.

49. The apparatus of claim 47, wherein n is a multiple of 3.

51. A method of filtering and drying a product comprising the steps of:

providing a product chamber and a vacuum chamber, the product chamber and the vacuum chamber sharing a porous wall;

delivering a product into the product chamber;

filtering a substance from the product through the porous wall; and

drying the product;

wherein the product comprises fine frozen particles and the substance comprises liquid nitrogen.

52. A method of filtering and drying a product comprising the steps of:

providing a product chamber and a vacuum chamber, the product chamber and the vacuum chamber sharing a porous wall;

delivering a product into the product chamber;

filtering a substance from the product through the porous wall; and

drying the product;

wherein the product comprises polymer microspheres.

53. A method of filtering and drying a product comprising the steps of:

providing a product chamber and a vacuum chamber, the product chamber and the vacuum chamber sharing a porous wall;

delivering a product into the product chamber;

filtering a substance from the product through the porous wall; and

drying the product;

wherein the product comprises a protein.

54. A method of filtering and drying a product comprising the steps of:

providing a product chamber and a vacuum chamber, the product chamber and the vacuum chamber sharing a porous wall;

delivering a product into the product chamber;

filtering a substance from the product through the porous wall; and

drying the product;

wherein the product comprises a drug.

55. A product filtered and dried according to a method of filtering and drying a product comprising the steps of:

providing a product chamber and a vacuum chamber, the product chamber and the vacuum chamber sharing a porous wall;

delivering a product into the product chamber;

filtering a substance from the product through the porous wall; and

drying the product.