Nutritional formula containing select carotenoid combinations

• US 7,090,879 B2
• Filed: 03/18/2004
• Issued: 08/15/2006
• Est. Priority Date: 03/18/2004
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Auestad, Nancy, Boff, Jeffrey M., Albrecht, Daniel S., Mackey, Amy
• Primary Examiner(s): HEGGESTAD, HELEN F
• Application Number:
  US10/803,485
• Publication Number:
  US 20050208179A1
• Time in Patent Office: 880 Days
• Field of Search: 426/72, 426/601, 426/262, 426/801
• US Class Current: 426/72
• CPC Class Codes: A23L 2/39 Dry compositions
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/156 Mineral combination undefined extract A23V2250/1638
• CPC Class Codes: A23V 2250/1862 Arachidonic acid
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/211 Carotene, carotenoids
• CPC Class Codes: A23V 2250/213 Lycopene
• CPC Class Codes: A23V 2250/70 Vitamins
• CPC Class Codes: A23V 2250/704 Vitamin B
• CPC Class Codes: Y10S 426/801 Pediatric

Abstract

Disclosed are nutritional formulas, including reconstitutable powders, comprising carbohydrate, protein and a lipid component containing a polyunsaturated fatty acid; and from about 0.25 to about 10 ppm, by weight of the total oil content of the infant formula, of a combination of lutein, lycopene, and beta-carotene with preferred weight ratios of the lutein to beta-carotene of from about 0.0196:1 to about 59:1, the lycopene to beta-carotene of from about 0.00805:1 to about 114:1, and the lutein to lycopene of from about 0.0117:1 to about 108:1. Also disclosed are methods of providing nutrition using the disclosed formulas. The nutritional formulas provide improved product stability and color characteristics.

Claims

1. A nutritional formula comprising

(A) carbohydrate,

(B) protein;

(C) lipid containing a polyunsaturated fatty acid; and

(D) from about 0.25 to about 11 ppm, by weight of the total oil content of the nutritional formula, of a combination of lutein, lycopene, and beta-carotene at the following weight ratios;

(i) lutein to beta-carotene of from about 0.0196;

1 to about 59;

1,

(ii) lycopene to beta-carotene of from about 0.00805;

1 to about 114;

1, and

(iii) lutein to lycopene of from about 0.0117;

1 to about 108;

1.

2. The nutritional formula of claim 1 wherein the formula comprises the following weight ratios:

(i) lutein to beta-carotene of from about 0.1;

1 to about 40;

1,

(ii) lycopene to beta-carotene of from about 0.01;

1 to about 60;

1, and

(iii) lutein to lycopene of from about 0.05;

1 to about 70;

1.

3. The nutritional formula of claim 1 wherein the formula comprises the following weight ratios:

(i) lutein to beta-carotene of from about 0.1;

1 to about 10;

1,

(ii) lycopene to beta-carotene of from about 0.1;

1 to about 10;

1, and

(iii) lutein to lycopene of from about 0.1;

1 to about 10;

1.

4. The nutritional formula of claim 1 wherein the combination of lutein, lycopene, and beta-carotene comprises from about 0.5 to about 8 ppm by weight of the total oil content of the nutritional formula.

5. The nutritional formula of claim 1 wherein the combination of lutein, lycopene, and beta-carotene comprises from about 1 to about 3 ppm by weight of the total oil content of the nutritional formula.

6. The nutritional formula of claim 1 wherein the formula comprises by weight of the total oil content of the formula from about 0.1 to about 5.16 ppm of lutein, from about 0.1 to about 9.8 ppm of lycopene, and from about 0.1 to about 5.9 ppm of beta-carotene.

7. The nutritional formula of claim 1 wherein the formula comprises by weight of the total oil content of the formula from about 0.5 to about 2.5 ppm of lutein, from about 0.2 to about 5 ppm of lycopene, and from about 0.1 to about 4 ppm of beta-carotene.

8. The nutritional formula of claim 1 wherein the polyunsaturated fatty acid represents from about 0.05% to about 20% by weight of total formula solids.

9. The nutritional formula of claim 8 wherein the polyunsaturated fatty acid comprises one or more of decosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, linoleic acid, linolenic acid, or combinations thereof.

10. The nutritional formula of claim 8 wherein the polyunsaturated fatty acid comprises decosahexaenoic acid.

11. The nutritional formula of claim 8 wherein the formula further comprises a combination of decosahexaenoic acid and arachidonic acid.

12. A method of providing nutrition to an infant, child, or adult, said method comprising administering to an infant, child, or adult the formula of claim 1.

13. A powder infant formula comprising

(A) carbohydrate,

(B) protein;

(C) lipid containing a polyunsaturated fatty acid; and

(D) from about 0.25 to about 10 ppm, the total oil content of the formula, of a combination from the group consisting essential of lutein, lycopene, and beta-carotene at the following weight ratios;

(i) lutein to beta-carotene of from about 0.0196;

1 to about 59;

1,

(ii) lycopene to beta-carotene of from about 0.00805;

1 to about 114;

1, and

(iii) lutein to lycopene of from about 0.0117;

1 to about 108;

1,

wherein the formula is a powder nutritional formula.

14. The nutritional formula of claim 13 wherein the formula comprises the following weight ratios:

(i) lutein to beta-carotene of from about 0.1;

1 to about 10;

1,

(ii) lycopene to beta-carotene of from about 0.1;

1 to about 10;

1, and

(iii) lutein to lycopene of from about 0.1;

1 to about 10;

1.

15. The nutritional formula of claim 13 wherein the combination of lutein, lycopene, and beta-carotene comprises from about 0.5 to about 8 ppm by weight of the total oil content of the nutritional formula.

16. The nutritional formula of claim 13 wherein the combination of lutein, lycopene, and beta-carotene comprises from about 1 to about 3 ppm by weight of the total oil content of the nutritional formula.

17. The nutritional formula of claim 13 wherein the formula comprises by weight of the total oil content of the nutritional formula from about 0.1 to about 5.16 ppm of lutein, from about 0.1 to about 9.8 ppm of lycopene, and from about 0.1 to about 5.9 ppm of beta-carotene.

18. The nutritional formula of claim 13 wherein the formula comprises by weight of the total oil content of the nutritional formula from about 0.5 to about 2.5 ppm of lutein, from about 0.2 to about 5 ppm of lycopene, and from about 0.1 to about 4 ppm of beta-carotene.

19. The nutritional formula of claim 13 wherein the polyunsaturated fatty acid represents from about 0.05% to about 20% by weight of total formula solids.

20. The nutritional formula of claim 19 wherein the polyunsaturated fatty acid comprises one or more of decosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, linoleic acid, linolenic acid, or combinations thereof.

21. The nutritional formula of claim 19 wherein the polyunsaturated fatty acid comprises decosahexaenoic acid.

22. The nutritional formula of claim 19 wherein the formula further comprises a combination of decosahexaenoic acid and arachidonic acid.

23. The infant formula of claim 22 wherein the polyunsaturated fatty acid represents from about 0.05% to about 15% by weight of total formula solids.

24. The infant formula of claim 23 wherein the polyunsaturated fatty acid comprises one or more of decosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, linoleic acid, linolenic acid, or combinations thereof.

25. The infant formula of claim 23 wherein the polyunsaturated fatty acid comprises decosahexaenoic acid.

26. The infant formula of claim 23 wherein the formula further comprises a combination of decosahexaenoic acid and arachidonic acid.

27. A method of providing nutrition to an infant, child, or adult, said method comprising reconstituting the formula of claim 13 with water to form a ready-to-feed liquid, and then feeding the infant, child, or adult with the reconstituted formula.

28. An infant formula comprising

(A) carbohydrate,

(B) protein;

(B) lipid containing arachidonic acid and decosahexaenoic acid; and

(C) from about 0.25 to about 10 ppm of a combination from the group consisting essentially of lutein, lycopene, and beta-carotene, by weight of the total oil content of the infant formula.

29. The infant formula of claim 28 wherein the combination of lutein, lycopene, and beta-carotene represents from about 0.5 to about 8 ppm of the total oil content of the infant formula.

30. The infant formula of claim 28 wherein the combination of lutein, lycopene, and beta-carotene represents from about 1 to about 3 ppm of the total oil content of the infant formula.

31. The infant formula of claim 28 wherein the formula comprises, by weight of the total oil content of the infant formula, from about 0.1 to about 5.16 ppm of lutein, from about 0.1 to about 9.8 ppm of lycopene, and from about 0.1 to about 5.9 ppm of beta-carotene.

32. The infant formula of claim 28 wherein the formula comprises, by weight of the total oil content of the infant formula, from about 0.5 to about 2.5 ppm of lutein, from about 0.2 to about 5 ppm of lycopene, and from about 0.1 to about 4 ppm of beta-carotene.

33. The infant formula of claim 28 wherein the formula is in powder form.

34. A method of providing nutrition to an infant, said method comprising reconstituting the formula of claim 33 with water to form a ready-to-feed liquid, and then feeding the infant with the reconstituted formula.

35. The infant formula of claim 28 wherein the formula is in liquid form.

36. A method of providing nutrition to an infant, said method comprising administering to an infant the formula of claim 28.