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Enhanced diffraction-based biosensor devices

  • US 7,091,049 B2
  • Filed: 06/26/2002
  • Issued: 08/15/2006
  • Est. Priority Date: 06/26/2002
  • Status: Active Grant
First Claim
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1. A method of detecting an analyte of interest in a medium with a diffraction based biosensor having at least one additional detection tag mechanism, comprising:

  • exposing a detection tag material to the medium, the detection tag material tagging the analyte of interest with a measurable parameter in addition to optical diffraction characteristics of the analyte of interest;

    exposing a biosensor to the medium, the biosensor having a substrate member with a receptive material layer applied to at least one side thereof wherein the receptive material is specific for the analyte of interest such that the analyte binds to the receptive material;

    separating an unbound detection tag material from a bound detection tag material tagging the analyte of interest;

    exposing the biosensor to a light source and detecting the presence of the analyte by detecting a diffraction pattern of the transmitted light or reflected light; and

    detecting the emitted measurable parameter of the detection tag material.

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