Phosphorus-containing compounds and uses thereof
3 Assignments
0 Petitions
Accused Products
Abstract
This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which:
- A is absent or is —O—, —S— or —NR2—;
- Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA;
-
- K is O or S;
- each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P;
- each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and
- each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H;
- wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring;
- each occurrence of G is independently —O—, —S—, —NR2— or (M)x;
- each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated;
- each occurrence of x is independently an integer from 1–6; and the other variables are as defined herein.
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Citations
36 Claims
- 1. A compound of the formula:
- 2. A compound of the formula:
- 3. A compound of the formula:
- 4. A compound of the formula:
-
22. A rapamycin or 43-epi-rapamycin in which the hydroxyl group at position 43 is replaced by a group JQA-, wherein:
-
A is —
O—
, —
S—
or —
NR2—
or is absent;Q is absent or (if A is —
O—
, —
S—
or —
NR2—
) Q may be —
V—
, —
OV—
, —
SV—
, or —
NR2V—
, where V is an unsubstituted aliphatic or heteroaliphatic, an aryl, or a 5–
14 membered heteroaryl moiety having 1–
4 heteroatoms selected from nitrogen, oxygen, or sulfur, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; - View Dependent Claims (23, 24, 25, 26)
-
-
27. A compound of the formula:
- 28. A compound of the formula
Specification