Rate-adaptive therapy with sensor cross-checking

• US 7,092,758 B2
• Filed: 02/10/2003
• Issued: 08/15/2006
• Est. Priority Date: 08/15/2000
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Lang, Douglas J., Sun, Weimin, Jones, Bruce R.
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): Kramer, Nicole R.
• Application Number:
  US10/364,129
• Publication Number:
  US 20030120319A1
• Time in Patent Office: 1,282 Days
• Field of Search: 607 17- 19, 607/20
• US Class Current: 607/18
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A method and system for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker in which maximum exertion levels attained by the patient are measured at periodic intervals and stored in order to compute or update a maximum exercise capacity. The slope of the rate-response curve is then adjusted to map an exertion level corresponding to the updated maximum exercise capacity to a maximum allowable pacing rate. In accordance with the invention, a maximum exercise capacity is determined by cross-checking periodic maximum exertion level sensor values with a motion-level sensor value.

Claims

1. A system, comprising:

level sensor for measuring exertion levels;

an activity level sensor;

a processor coupled to the exertion level sensor and the activity level sensor;

a pulse generator coupled to the processor for delivering pacing pulses in accordance with a rate-adaptive pacing mode based upon a rate-response curve; and

,

wherein the processor is programmed to;

determine a resting exertion level from the measured exertion levels;

determine a maximum exertion level from the measured exertion levels;

associate the maximum exertion level with a corresponding activity level;

estimate a maximum exercise capacity by cross-checking the maximum exertion level with the corresponding activity level; and

adjust a response factor based on the estimated maximum exercise capacity and the resting exertion level, the response factor being a slope of the rate-response curve in a rate-adaptive cardiac pacing mode.

2. The system of claim 1, further comprising:

an atrial sensing and pacing channel communicatively coupled to the processor; and

a ventricular sensing and pacing channel communicatively coupled to the processor.

3. The system of claim 2, further comprising at least one moving average filter, coupled to the exertion level sensor, to remove spurious peaks in signals sensed by the activity level sensor.

4. The system of claim 2, further comprises at least one moving average filter, coupled to the activity level sensor, to remove spurious peaks in signals sensed by the activity level sensor.

5. The system of claim 2, wherein the exertion level sensor comprises a minute ventilation sensor.

6. The system of claim 2, wherein the activity level sensor comprises an accelerometer.

7. A method, comprising:

measuring exertion levels;

measuring activity levels;

determining a resting exertion level from the measured exertion levels;

determining a maximum exertion level from the measured exertion levels;

associating the maximum exertion level with a corresponding activity level;

estimating a maximum exercise capacity by cross-checking the maximum exertion level with the corresponding activity level; and

adjusting a response factor based on the estimated maximum exercise capacity and the resting exertion level, the response factor being a slope of a rate-response curve in a rate-adaptive cardiac pacing mode.

8. The method of claim 7, further comprising defining a minimum value for the response factor.

9. The method of claim 7, further comprising determining a maximum target heart rate and a minimum target heart rate, and wherein adjusting the response factor comprises adjusting the response factor based on the maximum target heart rate, the minimum target heart rate, the maximum exercise capacity, and the resting exertion level.

10. The method of claim 9, wherein adjusting the response factor comprises determining the response factor using an equation:

RF=(MaxHR−

MinHR) / (MEC−

REL),

where RF is the response factor, MaxHR is the maximum target heart rate, MinHR is the minimum target heart rate, MEC is the maximum exercise capacity, and REL is the resting exertion level.

11. The method of claim 10, further comprising determining the minimum target heart rate and the resting exertion level after an implantation of a rate-adaptive pacemaker.

12. The method of claim 11, further comprising determining an initial value of the maximum target heart rate based on population data and age.

13. The method of claim 7, wherein determining the maximum exertion level comprises determining a periodic maximum exertion level.

14. The method of claim 13, wherein determining the periodic maximum exertion level comprises:

collecting a plurality of first maximum exertion levels each determined from exertion levels measured over a predetermined first period; and

selecting a highest exertion level among the plurality of first maximum exertion levels collected over a predetermined second period.

15. The method of claim 14, wherein determining the periodic maximum exertion level comprises:

collecting a plurality of daily maximum exertion levels over a predetermined period; and

selecting the highest exertion level among the plurality of daily exertion levels.

16. The method of claim 14, wherein estimating the maximum exercise capacity comprises:

estimating a plurality of first periodic maximum exercise capacities by cross-checking each of the plurality of first maximum exertion levels with its corresponding activity level; and

selecting the maximum exercise capacity from the plurality of first periodic maximum exercise capacities.

17. The method of claim 7, further comprising removing spurious peaks in at least one of the measured exertion levels and the measured activity levels.

18. The method of claim 17, wherein removing spurious peaks in at least one of the measured exertion levels and the measured activity levels comprises using a moving average filter to remove the spurious peaks.

19. The method of claim 7, further comprising mapping the corresponding activity level to a percentage of a reserve exercise capacity being the difference between the maximum exercise capacity and the rest exertion level, and wherein the cross-checking comprises dividing the maximum exertion level by the percentage of the reserve exercise capacity represented by the corresponding activity level.

20. The method of claim 19, furthering comprising defining a minimum value for the percentage of the reserve exercise capacity represented by the corresponding activity level.

21. A system comprising:

means for measuring exertion levels and determining resting and maximum exertion levels;

means for measuring activity levels and associating the maximum exertion level with a corresponding activity level measurement;

means for estimating a maximum exercise capacity by cross-checking the maximum exertion level with the corresponding activity level measurement;

means for delivering pacing pulses in accordance with a rate-adaptive pacing mode based upon a rate-response curve; and

,

means for adjusting a response factor based on the estimated maximum exercise capacity and the resting exertion level, the response factor being a slope of the rate-response curve in the rate-adaptive cardiac pacing mode.

22. The system of claim 21, further comprising means for mapping activity levels to percentages of reserve exercise capacity, and wherein the means for estimating the maximum exercise capacity comprises means for cross-checking the maximum exertion level with the corresponding activity level measurement by dividing the maximum exertion level by the percentage of reserve exercise capacity mapped to by the corresponding activity level measurement.

23. The system of claim 22, wherein the means for mapping activity levels to percentages of reserve exercise capacity comprises means for mapping the activity levels to the percentages of reserve exercise capacity by a linear relationship.

24. The system of claim 22, wherein the means for mapping activity levels to percentages of a reserve exercise capacity comprises means for mapping the activity levels to discrete percentages of reserve exercise capacity according to predetermined activity level thresholds.

25. The system of claim 21, further comprising:

means for determining a plurality of periodic maximum exertion levels;

means for cross-checking the plurality of periodic maximum exertion levels; and

means for estimating the maximum exercise capacity as a maximum among the plurality of cross-checked periodic maximum exertion levels.