Method of optimizing cardiac resynchronization therapy using sensor signals of septal wall motion

• US 7,092,759 B2
• Filed: 07/30/2003
• Issued: 08/15/2006
• Est. Priority Date: 07/30/2003
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sheldon, Todd J., Nehls, Robert J.
• Primary Examiner(s): Pezzuto, Robert E.
• Assistant Examiner(s): Reidel, Jessica L.
• Application Number:
  US10/631,551
• Publication Number:
  US 20050027320A1
• Time in Patent Office: 1,112 Days
• Field of Search: 607 17- 19, 607 9- 10, 607/15, 600/508, 600/587
• US Class Current: 607/19
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

The present invention relates to monitoring septal wall motion of the atrial and/or ventricular chambers of a heart for optimizing cardiac pacing intervals based on signals derived from the monitored wall motion. At least one lead of medical device is equipped with a motion sensor adapted to couple to septal tissue. The device receives and may post-process (e.g., suitably filter, rectify and/or integrate) motion signals to determine acceleration, velocity and/or displacement. During pacing interval optimization the wall motion is measured for those pacing intervals and the pacing interval setting(s) that produce minimal wall motion for chronic therapy delivery. In addition, methods for periodically determining whether to cease or resume delivery of a bi-ventricular pacing therapy to a patient that may have experienced beneficial reverse remodeling of the heart.

Claims

1. A system for providing optimized cardiac chamber synchronization to a patient during delivery of cardiac pacing therapy, comprising:

means for sensing a depolarization event of and/or providing a pacing stimulus to at least two chambers of a heart;

a single means for sensing acceleration, velocity or displacement of only a portion of an interchamber septal wall tissue of the heart disposed between said at least two chambers of the heart and providing a displacement signal thereof to the means for sensing a depolarization event and/or providing pacing stimulus; and

means for adjusting the timing for providing pacing stimulus to said heart to reduce or maintain the magnitude of the sensed displacement signal.

2. A system according to claim 1, wherein the at least two chambers of the heart comprise a left ventricle and a right ventricle.

3. A system according to claim 1, wherein the means for sensing comprises an accelerometer.

4. A system according to claim 3, wherein the accelerometer comprises a multi-axis accelerometer.

5. A system according to claim 1, wherein the means for adjusting timing is a programmable implantable medical device, said programmable implantable medical device further comprising a therapy delivery means for providing electrical stimulation therapy to said chambers and at least a one of:

an adjustable V—

V delay interval, an adjustable A—

A delay interval, an adjustable A-V delay interval.

6. A system according to claim 3, further comprising an accelerometer adapted to be coupled to a portion of inter-atrial septal tissue.

7. A system according to claim 1, wherein said means for sensing acceleration, velocity or displacement comprises a one of:

an optical sensor;

an acoustical sensor;

a Hall effect sensor;

a sensor having piezoelectric-, inductive-, capacitive-, resistive-elements, said sensor producing a variable signal proportional to septal wall motion or acceleration.

8. A method for providing optimized, closed-loop inter-chamber depolarization synchronization to a patient, consisting of:

providing pacing stimulus to at least two chambers of a heart;

sensing acceleration, velocity, or displacement using only portion of interchamber septal wall tissue of the heart and providing a displacement signal thereof; and

adjusting a delay interval for a pacing stimulus to a one of said at least two chambers of the heart to reduce or maintain the magnitude of the displacement signal.

9. A method according to claim 8, wherein said at least two chambers comprise a left ventricle and a right ventricle.

10. A method according to claim 8, wherein said means for sensing comprises an accelerometer.

11. A method according to claim 10, wherein said accelerometer comprises a multi-axis accelerometer.

12. A method according to claim 10, wherein the means for adjusting timing is a programmable implantable medical device, said programmable implantable medical device further comprising a therapy delivery means for providing electrical stimulation therapy to said chambers and further comprising, at least partially in response to the displacement signal, adjusting at least a one of:

an adjustable V—

V delay interval,

an adjustable A—

A delay interval,

an adjustable V-A delay interval,

an adjustable A-V delay interval.

13. A method according to claim 12, further comprising coupling an accelerometer to a portion of inter-atrial septal tissue.

14. A method according to claim 8, wherein said sensing step is carried out by a one of:

an optical sensor;

an acoustical sensor;

a Hall effect sensor;

a sensor having piezoelectric-, inductive-, capacitive-, resistive-elements, said sensor which produce a variable signal proportional to septal wall motion or acceleration.

15. A computer-readable medium for storing instructions to perform a method for providing optimized, closed-loop cardiac resychronization therapy (CRT) to a patient, consisting of:

instructions for sensing a depolarization of and/or providing pacing stimulus to at least two chambers of a heart;

instructions for sensing acceleration, velocity or displacement using only a portion of interchamber septal wall tissue of the heart and providing a displacement signal thereof; and

instructions adjusting a delay timing interval for a pacing stimulus to a one of said at least two chambers of the heart to reduce or maintain the magnitude of the displacement signal.

16. A method for monitoring left ventricular function, comprising:

deploying a motion sensor to a fixed location relative to a portion of a septal wall wherein the sensor generates a motion signal proportional to motion of the septal wall;

opening a data collection window during a portion of a selected cardiac cycle phase;

storing the motion signal throughout at least a part of the portion of the data collection window for a predetermined time interval or for more than one cardiac cycle;

verifying a stability characteristic of the motion signal during the predetermined time interval or for more than one cardiac cycle; and

determining a signal characteristic from the stored signal that is representative only of septal wall motion during delivery of a one of;

an atrial-based pacing therapy, an atrial-stimulation-only pacing therapy, a cardiac resynchronization therapy, a cardioversion therapy, a defibrillation therapy, a ventricular-stimulation-only pacing therapy.

17. A method according to claim 16, wherein said motion sensor is adapted to be disposed in a portion of inter-atrial tissue.

18. A method according to claim 17, wherein said motion sensor comprises an accelerometer.

19. A method according to claim 18, wherein the accelerometer comprises a uniaxial accelerometer having a longitudinal sensing axis substantially disposed orthogonal with respect to an adjacent surface of septal tissue.

20. A method according to claim 17, wherein said motion sensor comprises a biaxial accelerometer.

21. A method according to claim 17, wherein said motion sensor comprises a triaxial accelerometer.

22. A computer readable medium programmed with instructions for performing a method for optimizing cardiac pacing intervals in a device programmed to operate a bi-ventricular cardiac pacing modality, comprising:

instructions for sensing motion of a portion of a septal tissue of a heart with a deployed motion transducer and for providing a motion signal from the motion transducer;

instructions for opening a data collection window during a portion of a selected cardiac cycle phase;

instructions for storing the motion signal throughout at least a part of the portion of the data collection window for a predetermined time interval or for more than one cardiac cycle;

instructions for verifying a stability characteristic of the motion signal during the predetermined time interval or for more than one cardiac cycle;

instructions for averaging the stored motion signal; and

instructions for determining a signal characteristic from the averaged stored signal that is representative of only septal wall motion.

23. A computer readable medium according to claim 22, wherein said motion sensor is adapted to be disposed in a portion of inter-atrial septal tissue.

24. A computer readable medium according to claim 23, wherein said motion sensor comprises an accelerometer.

25. A computer readable medium according to claim 24, wherein the accelerometer comprises a uniaxial accelerometer having a longitudinal sensing axis disposed substantially perpendicular to an adjacent surface of tissue.

26. A computer readable medium according to claim 23, wherein said motion sensor comprises a biaxial accelerometer.

27. A computer readable medium according to claim 23, wherein said motion sensor comprises a triaxial accelerometer.

28. A computer readable medium according to claim 22, wherein the device comprises an implantable medical device.

29. A computer readable medium according to claim 25, wherein the first pacing electrode or the second pacing electrode further comprises a sense electrode in electrical communication with a sensing circuit coupled to the device and further comprising:

instructions for measuring depolarization wave activity and at least temporarily storing at least one parameter related to the measured depolarization wave activity.

30. A method for optimizing cardiac pacing intervals based septal wall motion comprising;

placing a motion sensor adapted for chronic in vivo implantation into electromechanical communication with only a portion of septal tissue so that the motion sensor generates a single

dedicated motion signal proportional to the motion of the portion of septal tissue;

enabling a temporal data collection window corresponding to a selected cardiac cycle phase;

applying a cardiac pacing stimulus delivered according to a preselected set of test pacing parameters;

sensing the motion signal during at least a part of the temporal data collection window or during a more than one cardiac cycle for at least some members of the preselected set of test pacing parameters;

determining a signal characteristic from the sensed signal that is representative of relatively improved left ventricular function during each of the selected test pacing parameters; and

storing a cardiac pacing timing parameter for a right ventricular pacing electrode and for a left ventricular pacing electrode that resulted in the single dedicated motion signal having the least magnitude.

31. An apparatus for optimizing cardiac function, comprising:

means for sensing motion of a portion of ventricular septal tissue and providing a motion signal;

means for stimulating a first ventricular chamber and a second ventricular chamber at the same moment and at different moments during a single cardiac cycle;

means for storing the sensed motion signals during a temporal window when the first ventricular chamber and the right ventricular chamber are stimulated at the same moment and at different moments;

means for mathematically integrating the sensed motion signals at least once during a period of time corresponding to when the first ventricular chamber and the right ventricular chamber are contracting;

means for comparing the mathematically integrated motion signals and determining a set of pacing parameters corresponding to an integrated motion signal having the least magnitude; and

means for storing the set of pacing parameters.

32. An apparatus according to claim 31, further comprising:

means for applying the stored set of pacing parameters in a cardiac pacing device.

33. A method of determining if a bi-ventricular pacing therapy should be delivered to a patient, comprising:

measuring a motion parameter of a portion of ventricular septal wall tissue during a period of time when an atrial-based pacing therapy is being delivered to a patient;

comparing the measured motion parameter to either a predetermined therapy selection threshold or a prior measurement of ventricular wall motion of said patient which was obtained during a prior period of time when the atrial-based pacing therapy was being delivered; and

in the event that the measured motion parameter either does not exceed the predetermined therapy selection threshold or exceeds the prior measurement, then withholding delivery of a bi-ventricular pacing therapy, or

in the event that the measured motion parameter exceeds the predetermined therapy selection threshold or exceeds the prior measurement, then resuming delivery of the bi-ventricular pacing therapy.

34. A method according to claim 33, wherein said motion parameter comprises a one of:

an acceleration parameter, a velocity parameter, a displacement parameter.

35. A method according to claim 33, wherein the bi-ventricular pacing therapy comprises a cardiac resynchronization therapy.

36. A method according to claim 33, wherein the atrial-based pacing therapy comprises a one of:

an AAI pacing therapy, an ADI pacing therapy, an AAI/R pacing therapy, an ADI/R pacing therapy.

37. A computer readable medium for storing executable instructions for performing a method of determining if a bi-ventricular pacing therapy should be delivered to a patient, comprising:

instructions for measuring a motion parameter of a portion of ventricular septal wall tissue during a period of time when an atrial-based pacing therapy is being delivered to a patient;

instructions for comparing the measured motion parameter to either a predetermined therapy selection threshold or a prior measurement of ventricular wall motion of said patient which was obtained during a prior period of time when the atrial-based pacing therapy was being delivered; and

instructions for withholding delivery of a bi-ventricular pacing therapy in the event that the measured motion parameter either does not exceed the predetermined therapy selection threshold or does not exceed the prior measurement, or

instructions for resuming delivery of the bi-ventricular pacing therapy in the event that the measured motion parameter exceeds the predetermined therapy selection threshold or exceeds the prior measurement.

38. A method according to claim 37, wherein said motion parameter comprises a one of:

an acceleration parameter, a velocity parameter, a displacement parameter.

39. A method according to claim 38, wherein the bi-ventricular pacing therapy comprises a cardiac resynchronization therapy.

40. A method according to claim 37, wherein the atrial-based pacing therapy comprises a one of:

an AAI pacing therapy, an ADI pacing therapy, an AAI/R pacing therapy, an ADI/R pacing therapy.