Gels, composites, and health care articles

• US 7,093,599 B2
• Filed: 04/21/2003
• Issued: 08/22/2006
• Est. Priority Date: 04/19/1994
• Status: Expired due to Fees

• Current Assignee: Applied Elastomerics Incorporated
• Original Assignee: Applied Elastomerics Incorporated
• Inventors: Chen, John Y.
• Primary Examiner(s): Lilling, Herbert J.
• Application Number:
  US10/420,491
• Publication Number:
  US 20040116591A1
• Time in Patent Office: 1,219 Days
• Field of Search: 524/270, 524/505, 524/575, 523/218, 428/401, 428/378, 428/319.3, 424/401, 424/439, 132/321, 280/742, 174/137.A, 174/174.B, 128/117.1, 128/206.12, 128/206.21, 128/112.1, 128/113.1, 604/262, 604/263, 604/408, 604/410, 604/411
• US Class Current: 602/1
• CPC Class Codes: A61M 2005/3109 Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
• CPC Class Codes: C08L 101/005 Dendritic macromolecules
• CPC Class Codes: C08L 2205/06 having improved processability or containing aids for moulding methods
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 53/025 modified
• CPC Class Codes: Y10T 428/249991 Synthetic resin or natural rubbers
• CPC Class Codes: Y10T 428/2938 Coating on discrete and individual rods, strands or filaments
• CPC Class Codes: Y10T 428/298 Physical dimension

Abstract

Gel and gel composites health care articles, including masks, pads, blood bags, tubings, male and female tubing connectors, and needle protector sheath.

Claims

1. A health care device comprising a gel article selected from a mask, a pad use in wound healing, a pad use for compression at a needle injection site to prevent injury to a blood vessel, a blood bag, a tubing for medical fluids, a tubing as one or more parts of a medical fluid sets, a male and female tubing connectors, and a needle projector sheath;

said gel article made from a gelatinous elastomer composition comprising;

(i) 100 parts by weight of one or more of a hydrogenated poly(styrene-isoprene/butadiene-styrene) block copolymer(s) and from

(ii) about 300 to about 1,600 parts by weight of a plasticizing oil; and

in combination with or without

(iii) a selected amount of one or more polymers or copolymers of poly(styrene-butadiene-styrene), poly(styrene-butadiene)_n, poly(styrene-isoprene-styrene)_n, poly(styrene-isoprene)_n, poly(styrene-ethylene-propylene), poly(styrene-ethylene-propylene-styrene), poly(styrene-ethylene-butylene-styrene), poly(styrene-ethylene-butylene), poly(styrene-ethylene-propylene)_n, poly(styrene-ethylene-butylene)_n, polystyrene, polybutylene, poly(ethylene-propylene), poly(ethylene-butylene), polypropylene, or polyethylene, wherein said selected copolymer is a linear, radial, star-shaped, branched or multiarm copolymer, wherein n is greater than one;

said gel article formed by injection molding, extruding, spinning, casting, or dipping of said gelatinous elastomer composition.

5. A health care device of claim 1, 2, 3, or 4, wherein said hydrogenated styrene block copolymer is one or more of a block copolymer of poly(styrene-ethylene-ethylene-propylene-styrene).

6. A health care device of claim 1 or 4, wherein a source of said hydrogenated poly(styrene-isoprene/butadiene-styrene) block polymer poly(styrene-ethylene-ethylene-propylene-styrene) block copolymer.

7. A health device of claim 1, 2, 3, or 4, wherein said one or more (i) block copolymer(s) is poly(styrene-ethylene-ethylene-propylene-styrene).

12. A health care devive according to claims 1, 2, 3, or 4, wherein said one or more (i) block copolymers is made from poly(styrene-ethylene-ethylene-propylene styrene).

2. A health care device comprising a composite article selected from a mask, a pad use in wound healing, a pad use for compression at a needle injection site to prevent injury to a blood vessel, a blood bag, a tubing for medical fluids, a tubing as one or more parts of a medical fluid sets, a male and female tubing connectors, and a needle protector sheath;

said composite article comprising a gelatinous elastomer composition, G, in contact with one or more of a selected substrate material, M, said gelatinous elastomer composition comprising;

(i) 100 parts by weight of one or a mixture of two or more of a hydrogenated poly(styrene-isoprene/butadiene-styrene) block copolymer(s) and

(ii) from about 300 to about 1,600 parts by weight of an plasticizing oil;

in combination with or without

(iii) a selected amount of one or more polymer or copolymer of poly(styrene-butadiene-styrene),poly(styrene-butadiene)_n, poly(styrene-isoprene-styrene), poly(styrene-isoprene)_n, poly(styrene-ethylene-propylene), poly(styrene-ethylene-propylene-styrene), poly(styrene-ethylene-butylene-styrene), poly(styrene-ethylene-butylene), poly(styrene-ethylene-propylene)_n, poly(styrene-ethylene-butylene)_n, polystyrene, polybutylene, poly(ethylene-propylene), poly(ethylene-butylene), polypropylene, or polyethylene, wherein said selected copolymer is a linear, radial, branched, star-shaped, or multiarm copolymer, and n is an integer greater than one;

wherein said composite formed from the combination G_nG_n, G_nG_nG_n, G_nM_n of said G_n of said G_n with M_n or two or more G_n without M;

wherein when n is a subscript of M, n is the same or different selected from the group consisting of foam, plastic, fabric, metal, ceramics, synthetic resin, synthetic fibers or refractory materials; and

wherein when n is a subscript of G, n denotes the same or a different gel rigidity; and

wherein when n is a subscript of G, without M, n denotes a different gel rigidity;

said composite article formed by injection molding, extruding, spinning, casting, or dipping of said gelatinous elastomer composition.

8. A health care devive composite of claim 2, 3, or 4 wherein said gel article formed by injection molding, extruding, spinning, casting, or dipping of said gelatinous elastomer compositon.

3. A health care device comprising a composite article selected from a mask, a pad use in wound healing, a pad use for compression at a needle injection site to prevent injury to a blood vessel, a blood bag, a tubing for medical fluids, a tubing as one or more parts of a medical fluid sets, a male and female tubing connectors, and a needle protector sheath;

said composite article comprising a gelatinous elastomer composition, G, in contact with one or more of a selected substrate material, M, said gelatinous elastomer composition comprising;

(i) 100 parts by weight of one or a mixture of two or more of a hydrogenated styrene block copolymer(s) with 2-methyl-1,3-butadiene and 1,3-butadiene and

(ii) from about 300 to about 1,600 parts by weight of an plasticizing oil;

in combination with or without

(iii) a selected amount of one or more selected polymer or copolymer selected from the group consisting of poly(styrene-butadiene-styrene), poly(styrene-butadiene), poly(styrene-isoprene-styrene), poly(styrene-isoprene), poly(styrene-ethylene-propylene), poly(styrene-ethylene-propylene-styrene), poly(styrene-ethylene-butylene-styrene), poly(styrene-ethylene-butylene), poly(styrene-ethylene-propylene)_n, poly(styrene-ethylene-butylene)_n, polystyrene, polybutylene, poly(ethylene-propylene), poly(ethylene-butylene), polypropylene, or polyethylene, wherein said selected copolymer is a linear, radial, branched, star-shaped, or multiarm copolymer; and

n is an integer greater than one, wherein said gelatinous elastomer compositions characterized by a gel rigidity of from about 20 to about 800 gram Bloom;

wherein said composite formed from the combination G_nG_n, G_nG_nG_n, G_nM_n, G_nM_nM_nG_n, G_nG_nM_nM_n, G_nM_nG_nM_nM_n, G_nM_nG_n, M_nG_nM_n, G_nG_nM_n, M_nM_nM_nG_n, M_nM_nM_nG_nM_n, M_nG_nG_nM_n, G_nM_nG_nG_n, G_nM_nM_nG_n, G_nG_nM_nM_n, G_nG_nM_nG_nM_n, G_nM_nG_nM_nM_n, M_nG_nM_nG_nM_nG_n, G_nG_nM_nM_nG_n, G_nG_nM_nG_nM_nG_n, G_na sequential addition or a permutation of one or more of said G_n with M_n or two or more G_n without M;

wherein when n is a subscript of M, n is the same or different selected from the group consisting of foam, plastic, fabric, metal, ceramics, synthetic resin, synthetic fibers or refractory materials; and

wherein when n is a subscript of G, n denotes the same or a different gel rigidity; and

wherein when n is a subscript of G, without M, n denotes a different gel rigidity;

said composite article formed by injection molding, extruding, spinning, casting, or dipping of said gelatinous elastomer composition.

4. A health care device comprising a composite article selected from a mask, a pad use in wound healing, a pad use for compression at a needle injection site to prevent injury to a blood vessel, a blood bag, a tubing for medical fluids, a tubing as one or more parts of a medical fluid sets, a male and female tubing connectors, and a needle protector sheath;

said composite article comprising a gelatinous elastomer composition, G, in contact with one or more of a selected substrate material, M, said gelatinous elastomer composition comprising;

(i) 100 parts by weight of one or a mixture of two or more of a hydrogenated poly(styrene-isoprene/butadiene-styrene) block copolymer(s), wherein at least one of said block copolymer is a high viscosity copolymer having a viscosity value at 5 weight percent solution in toluene at 30°

C. of about 90 cps and higher which corresponds to a viscosity at 10 weight percent of about 5800 cps and higher which corresponds to a viscosity at 20 weight percent solids solution in toluene at 25°

C. of at about 80,000 cps and higher, and

(ii) from about 300 to about 1,600 parts by weight of an plasticizing oil, and in combination with or without

(ii) a selected amount of one or more polymers or copolymers of poly(styrene-butadiene-styrene), poly(styrene-butadiene), poly(styrene-isoprene-styrene), poly(styrene-isoprene), poly(styrene-ethylene-propylene), poly(styrene-ethylene-propylene-styrene), poly(styrene-ethylene-butylene-styrene), poly(styrene-ethylene-butylene), poly(styrene-ethylene-propylene)_n, poly(styrene-ethylene-butylene)_n, polystyrene, polybutylene, poly(ethylene-propylene), poly(ethylene-butylene), polypropylene, or polyethylene, wherein said selected copolymer is a linear, branched, radial, star-shaped, or multiarm copolymer; and

n is an integer greater than one;

wherein said composite formed from the combination G_nG_n, G_nG_nG_n, G_nM_n, G_nM_nG_n, M_nG_nM_n, G_nG_nM_n, M_nM_nM_nG_n, M_nM_nM_nG_nM_n, M_nG_nG_nM_n, G_nM_nG_nG_n, G_nM_nM_n, G_n, G_nG_nM_nM_n, G_nG_nM_nG_nM_n, G_nM_nG_nM_nM_n, M_nG_nM_nG_nM_nG_n, G_nG_nM_nM_nG_n, G_nG_nM_nG_nM_nG_n, a sequential addition or a permutation of one or more of said G_n with M_n,or two or more G_n without M;

wherein when n is a subscript of M, n is the same or different selected from the group consisting of foam, plastic, fabric, metal, ceramics, synthetic resin, synthetic fibers or refractory materials; and

wherein when n is a subscript of G, n denotes the same or a different gel rigidity; and

wherein when n is a subscript of G without M, n denotes a different gel rigidity;

said composite article formed by injection molding, extruding, spinning, casting, or dipping of said gelatinous elastomer composition.

9. A health care device comprising a composite article selected from a mask, a pad use in wound healing, a pad use for compression at a needle injection site to prevent injury to a blood vessel, a blood bag, a tubing for medical fluids, a tubing as one or more parts of a medical fluid sets, a male and female tubing connectors, and a needle protector sheath;

said composite article comprising a gelatinous elastomer composition, G, in contact with one or more of a selected substrate material, M, said gelatinous elastomer composition comprising;

(i) 100 parts by weight of one or more poly(styrene-ethylene-ethylene-propylene-strene) block copolymers and

(ii) from about 300 to about 1,600 parts by weight of an plasticizing oil, and in combination with or without

(iii) a selected amount of one or more polymers or copolymers of poly(styrene-butadiene-styrene), poly(styrene-butadiene)_n, poly(styrene-isoprene-styrene)_n, poly(styrene-isoprene)_n, poly(styrene-ethylene-propylene), poly(styrene-ethylene-propylene-styrene), poly(styrene-ethylene-butylene-styrene), poly(styrene-ethylene-butylene), poly(styrene-ethylene-propylene)_n, poly(styrene-ethylene-butylene)_n, polystyrene, polybutylene, poly(ethylene-propylene), poly(ethylene-butylene), polypropylene, or polyethylene, wherein said selected copolymer is a linear, radial, star-shaped, branched or multiarm copolymer, wherein n is greater than one;

wherein said composite formed from the combination G_nG_n, G_nG_nG_n, G_nM_n, G_nM_nG_n, M_nG_nM_n, G_nG_nM_n, M_nM_nM_nG_n, M_nM_nM_nG_nM_n, M_nG_nG_nM_n, G_nM_nG_nG_n, G_nM_nM_nG_n, G_nG_nM_nM_n, G_nG_nM_nG_nM_n, G_nM_nG_nM_nM_n, M_nG_nM_nG_nM_nG_n, G_nG_nM_nM_nG_n, G_nG_nM_nG_nM_nG_n, a sequential addition or a permutation of one or more of said G_n with M_n or two or more G_n without M;

wherein when n is a subscript of M, n is the same or different selected from the group consisting of foam, plastic, fabric, metal, ceramics, synthetic resin, synthetic fibers or refractory materials; and

wherein when n is a subscript of G, n denotes the same or a different gel rigidity; and

wherein when n is a subscript of G, without M, n denotes a different gel rigidity;

said composite article formed by injection molding, extruding, spinning, casting, or dipping of said gelatinous elastomer composition.

10. A health care device comprising a composite article selected from a mask, a pad use in wound healing, a pad use for compression at a needle injection site to prevent injury to a blood vessel, a blood bag, a tubing for medical fluids, a tubing as one or more parts of a medical fluid sets, a male and female tubing connectors, and a needle protector sheath;

said composite article comprising a gelatinous elastomer composition, G, in contact with one or more of as elected substrate material, M, said gelatinous elastomer composition comprising;

(i) 100 parts by weight of a block copolymer of one or more poly(styrene-ethylene-ethylene-propylene-styrene block copolymers and a source of said block copolymers being Septon®

4033, Septon®

4044, Septon®

(ii) from about 300 to about 1,600 parts by weight of an plasticizing oil;

wherein said composite formed from the combination G_nG_n, G_nG_nG_n, G_nM_n, G_nM_nG_n, M_nG_nM_n, G_nM_n, G_nM_nG_nG_n, G_nM_nM_nG_n, M_nG_nG_n, M_nM_nM_nG_n, M_nM_nM_nG_nG_nM_nM_n, G_nG_nM_nG_nM_n, G_nM_nG_nM_nM_n, M_nG_nM_nG_nM_nG_n, G_nG_nM_nM_nG_n, G_nG_nM_nG_nM_nG_n, a sequential addition or a permutation of one or more of said G_n with M_n or two or more G_n witout M;

wherein when n is a subscript of M, n is the same or different selected from the group consisting of foam, plastic, fabric, metal, ceramics, synthetic resin, synthetic fibers or refractory materials; and

wherein when n is a subscript of G, n denotes the same or a different gel rigidity; and

wherein when n is a subscript of G without M, n denotes a different gel rigidity;

said composite article formed by injection molding, extruding, spinning, casting, or dipping of said gelatinous elastomer compositon.

11. A health care device comprising a composite article selected from a mask, a pad use in wound healing, a pad use for compression at a needle injection site to prevent injury to a blood vessel, a blood bag, a tubing for medical fluids, a tubing as one or more parts of a medical fluid sets, a male and female tubing connectors, and a needle protector sheath;

said composite article comprising a gelatinous elastomer composition, G, in contact with one or more of a selected substrate material, M, said gelatinous elastomer composition comprising;

(i) 100 parts by weight of one or a mixture of two or more poly(styrene-ethylene-ethylene-propylene-styrene) block copolymers and

(ii) from about 300 to about 1,600 parts by weight of an plasticizing oil, and in combination with or without

(iii) a selected amount of one or more polymers or copolymers of poly(styrene-butadiene-styrene), poly(styrene-butadiene)n, poly(styrene-isoprene-styrene)_n, poly(styrene-isoprene)_n, poly(styrene-ethylene-propylene), poly(styrene-ethylene-propylene-styrene), poly(styrene-ethylene-butylene-styrene), poly(styrene-ethylene-butylene), poly(styrene-ethylene-propylene)_n, poly(styrene-ethylene-butylene)_n, polystyrene, polybutylene, poly(ethylene-propylene), poly(ethylene-butylene), polypropylene, or polyethylene, wherein said selected copolymer is a linear, radial, star-shaped, branched or multiarm copolymer, wherein n is greater than one;

wherein said gelatinous elastomer composition characterized by a gel rigidity of from about 20 to about 800 gram Bloom;

wherein said composite formed from the combination G_nG_n, G_nG_nG_n, G_nM_n, G_nM_nG_n, M_nG_nM_n, M_nG_nG_n, M_n M_nM_nG_n, M_nM_nM_nG_nM_n, M_nG_nG_nM_n, G_nM_nG_nG_n, G_nM_nM_nG_n, G_nG_nM_nM_n, G_nG_nM_nG_nM_n, G_nM_nG_nM_nM_n, M_nG_nM_nG_nM_nG_n, G_nG_nM_nM_nG_n, G_nG_nM_nG_nM_nG_n, a sequential addition or a permutation of one or more of said G_n with M_n or two or more G_n without M;

wherein when n is a subscript of M, n is the same or different selected from the group consisting of foam, plastic, fabric, metal, ceramics, synthetic resin, synthetic fibers or refractory materials; and

wherein when n is a subscript of G, n denotes a different gel rigidity; and

wherein when n is a subscript of G without M, n denotes the same or a different gel rigidity;

said composite article formed by injection molding, extruding, spinning, casting, or dipping of said geatinous elastomer composition.