Systems and methods for delivering drugs to selected locations within the body
First Claim
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1. A reservoir device for providing sustained delivery of a drug within the cardiovascular system of a patient, comprising:
- a substantially cylindrical frame adapted to expand between a collapsed condition for insertion into a blood vessel and an enlarged condition for engaging a wall of the blood vessel, the frame defining a longitudinal axis and a periphery; and
a flexible membrane attached to the frame, the membrane including a generally cylindrical periphery with transversely disposed end panels attached to the periphery to define a generally cylindrical reservoir having closed ends, a porous region being disposed along at least a portion of the periphery of the flexible membrane such that drug that has been injected into the reservoir will pass out of the reservoir through said porous regionat least one of said end panels being formed of material which can be penetrated by a hollow needle through which drug may be injected into the reservoir and which will automatically reseal after the needle is withdrawn.
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Abstract
An implantable reservoir device (400) including an enclosed membrane (408) on an expandable frame (402) that defines a reservoir (410) and includes a porous region (418). The reservoir device (400) may be deployed and expanded within a blood vessel, and may be filled in situ or prefilled with a drug that passes through the porous region (418). Alternatively, a pair of expandable endovascular blockers (500) may be used to isolate a section of a blood vessel which may be filled with a drug that may be absorbed by the surrounding tissue.
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Citations
10 Claims
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1. A reservoir device for providing sustained delivery of a drug within the cardiovascular system of a patient, comprising:
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a substantially cylindrical frame adapted to expand between a collapsed condition for insertion into a blood vessel and an enlarged condition for engaging a wall of the blood vessel, the frame defining a longitudinal axis and a periphery; and a flexible membrane attached to the frame, the membrane including a generally cylindrical periphery with transversely disposed end panels attached to the periphery to define a generally cylindrical reservoir having closed ends, a porous region being disposed along at least a portion of the periphery of the flexible membrane such that drug that has been injected into the reservoir will pass out of the reservoir through said porous region at least one of said end panels being formed of material which can be penetrated by a hollow needle through which drug may be injected into the reservoir and which will automatically reseal after the needle is withdrawn. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification