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Nucleic acid ligands to integrins

  • US 7,094,535 B2
  • Filed: 12/18/2001
  • Issued: 08/22/2006
  • Est. Priority Date: 06/10/1991
  • Status: Expired due to Fees
First Claim
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1. A method for detecting a site of deep vein thrombosis in an individual, the method comprising:

  • (a) providing a nucleic acid ligand to a α

    vβ

    3 or α

    IIbβ

    3 mtegrm dimer, wherein said ligand binds to a nucleic acid binding site in said integrin β

    3 and said nucleic acid ligand conjugated to a radioactive label and wherein said nucleic acid ligand is selected from Table 1, 2 or 3;

    (b) administering said nucleic acid ligand to said individual;

    (c) detecting the site of said thrombosis by analyzing the localization of said nucleic acid ligand using a radioimaging technique.

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