Antisense restenosis composition and method
First Claim
Patent Images
1. A method for treating a vascular injury site in a human patient by reducing restenosis at the site, said method comprising:
- administering to the patient, by intravascular delivery directly to the vascular injury site, a morpholino antisense compound having uncharged phosphorodiamidate intersubunit linkages of the form;
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having uncharged phosphorus-containing backbone linkages, and spanning the start codon of a human c-myc mRNA. Also disclosed are novel antisense compounds and compositions, and a method for assaying the effectiveness of antisense delivery and uptake to a target vessel region.
-
Citations
13 Claims
-
1. A method for treating a vascular injury site in a human patient by reducing restenosis at the site, said method comprising:
administering to the patient, by intravascular delivery directly to the vascular injury site, a morpholino antisense compound having uncharged phosphorodiamidate intersubunit linkages of the form; - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
8. A method for treating a vascular injury site in a human patient, said method comprising:
providing an intravascular stent wherein said stent or a coating on said stent contains a morpholino antisense compound in diffusible form, wherein the morpholino antisense compound has uncharged phosphorodiamidate intersubunit linkages of the form; - View Dependent Claims (9, 10, 11, 12, 13)
Specification