Catheter with cryogenic and heating ablation

• US 7,097,641 B1
• Filed: 12/09/1999
• Issued: 08/29/2006
• Est. Priority Date: 12/09/1999
• Status: Expired due to Fees

• Current Assignee: Medtronic CryoCath LP (Medtronic Plc)
• Original Assignee: CryoCath Technologies Incorporated (Medtronic Plc)
• Inventors: Milder, Frederic L., Wittenberger, Dan, Carroll, Sean, Abboud, Marwan, Arless, Steven G.
• Primary Examiner(s): Rollins, Rosiland
• Application Number:
  US09/457,958
• Time in Patent Office: 2,455 Days
• Field of Search: 606 20- 28, 606/33, 606/41, 607/96, 607/100, 607/101, 607/104, 607/105, 607/108
• US Class Current: 606/20
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/0268 with restriction of flow

Abstract

A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles. In one embodiment a microwave energy source operates at a frequency to extend beyond the thermal conduction depth, or to penetrate the cryogenic ice ball and be absorbed in tissue beyond an ice boundary, thus extending the depth and/or width of a single treatment locus. In another embodiment, the cooling and the application of RF energy are both controlled to position the ablation region away from the surface contacted by the electrode, for example to leave surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth. The driver or RF energy source may supply microwave energy at a frequency effective to penetrate the ice ball which develops on a cryocatheter, and different frequencies may be selected for preferential absorption in a layer of defined thickness at depth in the nearby tissue. The catheter may operate between 70 and minus 70 degrees Celsius for different tissue applications, such as angioplasty, cardiac ablation and tissue remodeling, and may preset the temperature of the tip or adjacent tissue, and otherwise overlay or delay the two different profiles to tailor the shape or position where ablation occurs or to speed up a treatment cycle.

Claims

1. A catheter for the cryotreatment of tissue, said catheter comprising:

a catheter body;

a controller operative for selectively regulating cryogenic cooling energy with heat ablation energy; and

,

a treatment tip positioned at the distal end of said catheter body, said treatment tip having;

a cooling segment operable at a temperature sufficient to freeze tissue, said cooling segment having a thermally conductive wall for contacting and thermally treating tissue in contact with said thermally conductive wall; and

an electrically-driven ablation assembly, said electrically-driven ablation assembly operable to apply heating ablation energy to said tissue,

wherein said cooling segment and said electrically-driven heating ablation assembly operable to apply heating ablation energy to said tissue,

wherein said cooling segment and said electrically-driven heating ablation assembly each effect tissue ablation;

wherein said electrically driven ablation assembly includes an electrode assembly for applying one of radio frequency and microwave energy; and

,

a microwave driver tuned for propagation through near tissue and preferential absorption beyond said near tissue to effect ablation at a depth within said tissue.

2. The catheter of claim 1, wherein said cooling segment is coolable to about −

70°

C.

3. The catheter of claim 2, wherein said cooling semgment is operable to ablate said contacted tissue to a predetermined cooled tissue boundary and said electrically-driven ablation assembly is operable to extend ablation beyond said predetermined cooled tissue boundary.

4. The catheter of claim 1, wherein said tip further comprises sensing electrodes, said sensing electrodes usable to cold-map cardiac tissue sites.

5. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment operate sequentially operable to effect tissue ablation.

6. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment are operable to selectively ablate tissue at a depth boundary of an ablation region.

7. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment are operable to prevent near field charring or icing during ablation.

8. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment are operable to maintain a non-ablating near field temperature while attaining an ablation temperature at a depth.

9. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment are sequentially operable to cryoablate said tissue and thaw said cryoablated tissue, wherein adjacent tissue is cooled for mapping as treated tissue is thawed.

10. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment are arranged to provide a predetermined tip temperature.

11. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment are selectively operable to achieve a predetermined tissue temperature prior to ablative treatment.

12. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment are operable to apply one of hypo-thermal and hyper-thermal treatment to said tissue.

13. The catheter of claim 1, wherein said electrically-driven ablation assembly and said cooling segment operate simultaneously to effect tissue ablation.

14. The catheter of claim 1, wherein said controller is a console.

15. The catheter of claim 1, wherein said controller is programmable.

16. The catheter of claim 1, wherein said controller regulates the cooling segment and the electrically-ablation assembly to simultaneously ablate target tissue.