Bioactive agent release coating and controlled humidity method
First Claim
1. A method for controlling the rate of release of a bioactive agent from a coating composition provided in vivo, the method comprising the steps of:
- a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates having alkyl chain lengths from 2 to 8 carbons and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate) having vinyl acetate concentrations of between about 8% and about 90% by weight, and b) applying the coating composition to a surface to provide a controlled bioactive agent release profile in vivo.
1 Assignment
0 Petitions
Accused Products
Abstract
A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
-
Citations
88 Claims
-
1. A method for controlling the rate of release of a bioactive agent from a coating composition provided in vivo, the method comprising the steps of:
-
a) providing a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates having alkyl chain lengths from 2 to 8 carbons and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate) having vinyl acetate concentrations of between about 8% and about 90% by weight, and b) applying the coating composition to a surface to provide a controlled bioactive agent release profile in vivo. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
-
-
38. A method for controlling the rate of release of one or more antiproliferative agents from a coating composition provided in vivo, the method comprising the steps of:
-
a) providing a composition comprising the antiproliferative agents in combination with a blend of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates having alkyl chain lengths from 2 to 8 carbons and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate) having vinyl acetate concentrations of between about 8% and about 90% by weight, and b) applying the coating composition to a surface to provide a controlled antiproliferative agent release profile in vivo. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
-
-
64. A method for controlling the rate of release of estradiol from a coating composition provided in vivo, the method comprising the steps of:
-
a) providing a composition comprising the estradiol in combination with a blend of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates having alkyl chain lengths from 2 to 8 carbons and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate) having vinyl acetate concentrations of between about 8% and about 90% by weight, and b) applying the coating composition to a surface to provide a controlled estradiol release profile in vivo. - View Dependent Claims (63, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79)
-
- 80. A combination comprising a device coated with a composition including estradiol in combination with a blend of polymers, including a first polymer component selected from the group consisting of polyalkyl(meth)acrylates with alkyl chain lengths from 2 to 8 carbons and aromatic poly(meth)acrylates, and a second polymer component comprising poly(ethylene-co-vinyl acetate) having vinyl acetate concentrations of between about 8% and about 90% by weight and adapted to provide controlled release of the estradiol when positioned in an aqueous environment.
Specification