Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom
First Claim
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1. A bone fusion device comprising:
- a) an implant to be inserted into bone; and
b) a bone-growth inducing substance on a surface of the implant, the bone-growth inducing substance comprising a copolymer containing a major amount of alkylene oxide units and a minor amount of units derived from a bioabsorbable monomer selected from the group consisting of glycolic acid, glycolide, lactic acid, lactide, p-dioxanone, trimethylene carbonate, trimethylene dimethylene carbonate, dioxepanone, alkylene oxalates, epsilon-caprolactone, and combinations thereof, said copolymer being endcapped with at least one lysine isocyanate group.
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Abstract
Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.
97 Citations
20 Claims
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1. A bone fusion device comprising:
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a) an implant to be inserted into bone; and b) a bone-growth inducing substance on a surface of the implant, the bone-growth inducing substance comprising a copolymer containing a major amount of alkylene oxide units and a minor amount of units derived from a bioabsorbable monomer selected from the group consisting of glycolic acid, glycolide, lactic acid, lactide, p-dioxanone, trimethylene carbonate, trimethylene dimethylene carbonate, dioxepanone, alkylene oxalates, epsilon-caprolactone, and combinations thereof, said copolymer being endcapped with at least one lysine isocyanate group. - View Dependent Claims (2, 3)
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4. A bone fusion device comprising:
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a) an implant to be inserted into bone; and b) a bone-growth inducing substance on a surface of the implant, the bone-growth inducing substance comprising a composition containing a plurality of lysine-based isocyanate endcapped absorbable star polymer molecules, said absorbable star polymer molecules including repeating units derived from one or more monomers selected from the group consisting of p-dioxanone, alkylene carbonates and mixtures thereof and said plurality of star polymer molecules having at least one terminal, reactive isocyanate group and being capable of undergoing cross-linking with each other when exposed to water thereby curing to provide a solid material. - View Dependent Claims (5, 6, 7, 8, 9, 10)
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11. A bone fusion device comprising:
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a) an implant to be inserted into bone; and b) a bone-growth inducing substance comprising a fluid composition containing a plurality of lysine-based isocyanate endcapped absorbable star polymer molecules wherein the plurality of lysine-based isocyanate endcapped absorbable star polymer molecules have the general formula;
CH2OR1—
(CHOR2)—
(CHOR3)—
(CHOR4) . . . (CHORn)—
CH2ORn+1 wherein;n equals 3, 4 or 5; R1, R2 . . . Rn+1 are the same or different and selected from the group of a hydrogen atom or (Z)m wherein Z can be different at each occurrence and comprises repeating units selected from the group consisting of; - View Dependent Claims (12, 13, 14)
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15. A coated surgical device comprising:
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a) a surgical article possessing a surface to be coated; and b) a coating comprising a copolymer containing a major amount of alkylene oxide units and a minor amount of units derived from a bioabsorbable monomer selected from the group consisting of glycolic acid, glycolide, lactic acid, lactide, p-dioxanone, trimethylene carbonate, trimethylene dimethylene carbonate, dioxepanone, alkylene oxalates, epsilon-caprolactone, and combinations thereof, said copolymer being endeapped with at least one lysine isocyanate group. - View Dependent Claims (16)
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17. A coated surgical device comprising:
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a) a surgical article possessing a surface to be coated; and b) a coating comprising a composition containing a plurality of lysine-based isocyanate endcapped absorbable star polymer molecules, said absorbable star polymer molecules including repeating units derived from one or more monomers selected from the group consisting of p-dioxanone, alkylene carbonates and mixtures thereof and said plurality of star polymer molecules having at least one terminal, reactive isocyanate group and being capable of undergoing cross-linking with each other when exposed to water thereby curing to provide a solid material. - View Dependent Claims (18)
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19. A coated surgical device comprising:
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a) a surgical article possessing a surface to be coated; and b) a coating derived from a fluid composition containing a plurality of lysine-based isocyanate endcapped absorbable star polymer molecules wherein the plurality of lysine-based isocyanate endcapped absorbable star polymer molecules have the general formula;
CH2OR1—
(CHOR2)—
(CHOR3)—
(CHOR4) . . . (CHORN)—
CH2ORN+1,wherein;
n equals 3, 4 or 5;R1, R2 . . . RN+1 are the same or different and selected from the group of a hydrogen atom or (Z)m wherein Z can be different at each occurrence and comprises repeating units selected from the group consisting of; - View Dependent Claims (20)
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Specification