Multi-attribute drug comparison
First Claim
1. A drug comparator for assessing the confusability of one or more target drugs and one or more reference drugs based on one or more attributes of each target drug and each reference drug, comprising:
- a name attribute comparator that performs a composite quantitative comparison of a name attribute of the one or more target drugs and the one or more reference drugs, and that generates one or more name-attribute similarity scores based on said comparison, each name-attribute similarity score representing a similarity of the compared name attributes, wherein the name attribute comparator comprises two or more analyzers selected from the group consisting of;
an orthographic analyzer that generates one or more name-attribute similarity scores based on one or more orthographic measures of the name attributes of the one or more target and reference drugs;
a phonetic analyzer that generates one or more name-attribute similarity scores based on one or more phonetic measures of the name attributes of the one or more target and reference drugs; and
a phonological analyzer that generates one or more name-attribute similarity scores based on one or more phonological measures of the name attributes of the one or more target and reference drugs.
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Abstract
A computer-implemented apparatus or method, or a software product, for generating a composite quantitative comparison of drug products based on multiple attributes of them. A set of name-attribute similarity scores are generated based on similarities among the names of selected target and reference drugs. A set of product-attribute similarity scores are generated based on similarities among product attributes of the selected target and reference drugs. A target drug confusability score is generated based on the confusability of the target drug as compared to a population of other drugs. The composite quantitative comparison is generated based on a composite of the name-attribute and product-attribute similarity scores, and the target confusability score. A set of one or more severity of confusion scores may also be included in the composite quantitative comparison. These scores are based on one or more indicators of the severity of the consequences to a patient of confusing the target and reference drugs so that, for example, the wrong drug is administered to the patient, or the correct drug is incorrectly administered. The name-attribute similarity scores may be generated based on orthographic, phonetic, and/or phonological analysis. The product-attribute similarity scores may be generated based on the drugs'"'"'strengths, indications, dosages, administration routes, manufacturers, pharmacological categories, storage requirements, colors, shapes, legal standing, trademark description, and/or other attributes. The composite quantitative comparison may include severity-weighted similarity scores or both similarity scores and severity of confusion scores. The severity of confusion indicators may include a therapeutic index and/or a contraindication index.
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Citations
47 Claims
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1. A drug comparator for assessing the confusability of one or more target drugs and one or more reference drugs based on one or more attributes of each target drug and each reference drug, comprising:
a name attribute comparator that performs a composite quantitative comparison of a name attribute of the one or more target drugs and the one or more reference drugs, and that generates one or more name-attribute similarity scores based on said comparison, each name-attribute similarity score representing a similarity of the compared name attributes, wherein the name attribute comparator comprises two or more analyzers selected from the group consisting of; an orthographic analyzer that generates one or more name-attribute similarity scores based on one or more orthographic measures of the name attributes of the one or more target and reference drugs; a phonetic analyzer that generates one or more name-attribute similarity scores based on one or more phonetic measures of the name attributes of the one or more target and reference drugs; and a phonological analyzer that generates one or more name-attribute similarity scores based on one or more phonological measures of the name attributes of the one or more target and reference drugs. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 29)
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18. A drug comparator for assessing the confusability of one or more target drugs and one or more reference drugs based on one or more attributes of each target drug and each reference drug, comprising:
a product attribute comparator that performs a composite quantitative comparison of at least one product attribute of the one or more target drugs and the one or more reference drugs, and that generates one or more product-attribute similarity scores based on said comparison, each product-attribute similarity score representing a similarity of the compared product attributes, wherein the product attribute comparator comprises any one or more comparators selected from the group consisting of; a strength comparator that generates at least a first product-attribute similarity score based on one or more dosage strengths of the target and reference drugs; an indication comparator that generates at least a second product-attribute similarity score based on one or more indicated uses of the target and reference drugs; a dosage form comparator that generates at least a third product-attribute similarity score based on one or more dosage forms of the target and reference drugs; an administration route comparator that generates at least a fourth product-attribute similarity score based on one or more administration routes of the target and reference drugs; a manufacturer comparator that generates at least a fifth product-attribute similarity score based on one or more manufacturers of the target and reference drugs; a pharmacological category comparator that generates at least a sixth product-attribute similarity score based on one or more pharmacological categories of the target and reference drugs; a storage requirements comparator that generates at least a seventh product-attribute similarity score based on one or more storage requirements of the target and reference drugs; a color comparator that generates at least an eighth product-attribute similarity score based on one or more colors of the target and reference drugs; a shape comparator that generates at least a ninth product-attribute similarity score based on one or more shapes of the target and reference drugs; a legal standing comparator that generates at least a tenth product-attribute similarity score based on one or more legal standings of the target and reference drugs; a trademark description comparator that generates at least an eleventh product-attribute similarity score based on one or more goods and services trademark descriptions of the target and reference drugs; and a schedule comparator that generates at least a twelfth product-attribute similarity score based on one or more dosage intervals of the target and reference drugs. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A drug comparator for assessing the confusability of one or more target drugs and one or more reference drugs based on one or more attributes of each target drug and each reference drug, comprising:
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a name attribute comparator that performs a composite quantitative comparison of a name attribute of the one or more target drugs and the one or more reference drugs, and that generates one or more name-attribute similarity scores based on said comparison, each name-attribute similarity score representing a similarity of the compared name attributes; and a product attribute comparator that performs a composite quantitative comparison of at least one product attribute of the one or more target drugs and the one or more reference drugs, and that generates one or more product-attribute similarity scores based on said comparison, each product-attribute similarity score representing a similarity of the compared product attributes, wherein the drug comparator automatically generates the attribute similarity scores upon receipt of an indication of the one or more target drugs. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A drug comparator for assessing the confusability of one or more target drugs and one or more reference drugs based on one or more attributes of each target drug and each reference drug, comprising:
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a name attribute comparator that performs a composite quantitative comparison of a name attribute of the one or more target drugs and the one or more reference drugs, and that generates one or more name-attribute similarity scores based on said comparison, each name-attribute similarity score representing a similarity of the compared name attributes; and a neighborhood density calculator that calculates a neighborhood density score for at least a first target drug of the one or more target drugs based on a number of a first set of reference drugs, wherein each of the first set of reference drugs has a determined distance from the first target drug that is not greater than a threshold distance, wherein each determined distance is a function of the one or more attribute similarity scores. - View Dependent Claims (42, 43)
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44. A drug comparator for assessing the confusability of one or more target drugs and one or more reference drugs based on one or more attributes of each target drug and each reference drug, comprising:
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a name attribute comparator that performs a composite quantitative comparison of a name attribute of the one or more target drugs and the one or more reference drugs, and that generates one or more name-attribute similarity scores based on said comparison, each name-attribute similarity score representing a similarity of the compared name attributes; and a neighborhood familiarity calculator that calculates a neighborhood familiarity score for at least a first target drug of the one or more target drugs based on a familiarity of the first target drug and the familiarity of each of a first set of reference drugs, wherein each of the first set of reference drugs has a determined distance from the first target drug that is not greater than a threshold distance, wherein each determined distance is a function of the one or more attribute similarity scores. - View Dependent Claims (45, 46, 47)
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Specification