Microfluidic ion-selective electrode sensor system
First Claim
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1. An ion-sensor system comprising:
- a sampler assembly comprising;
an elongated tube having a proximal end and a distal end and defining a chamber, the proximal end dimensioned to draw a fluid into the chamber by capillary action; and
a connector portion; and
an ion-sensor cartridge comprising;
an electrical connection portion interconnecting with the sampler assembly connector portion; and
a plurality of ion-selective electrodes.
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Abstract
Ion-selective electrode sensor systems, and methods of fabricating such systems, may be utilized to analyze microfluidic sample volumes, i.e., sample volumes on the order of 1 to 1000 microliters.
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Citations
25 Claims
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1. An ion-sensor system comprising:
a sampler assembly comprising; an elongated tube having a proximal end and a distal end and defining a chamber, the proximal end dimensioned to draw a fluid into the chamber by capillary action; and a connector portion; and
an ion-sensor cartridge comprising;an electrical connection portion interconnecting with the sampler assembly connector portion; and a plurality of ion-selective electrodes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of fabricating an ion-sensor system, the method comprising the steps of:
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providing a substrate; forming a plurality of ion-selective electrode regions on the substrate; dividing the substrate into a plurality of strips such that each strip contains a plurality of ion-selective electrodes, providing a sampler assembly comprising an elongated tube having a proximal end and a distal end and defining a chamber, the proximal end dimensioned to draw a fluid into the chamber by capillary action, and disposing the strips within the chamber in electrical communication with the sampler assembly. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of measuring one or more electrolytes in blood, the method comprising the steps of:
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extracting blood from a subject; transferring the blood to an ion-sensor cartridge comprising an ion-selective electrode and disposed within a sampler assembly comprising an elongated tube having a proximal end and a distal end and defining a chamber, the proximal end dimensioned to draw the blood into the chamber by capillary action; and analyzing one or more electrolytes in the blood. - View Dependent Claims (24, 25)
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Specification