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System and method for determining optimal reaction parameters using continuously running process

  • US 7,101,515 B2
  • Filed: 04/14/2004
  • Issued: 09/05/2006
  • Est. Priority Date: 04/14/2003
  • Status: Expired due to Fees
First Claim
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1. An automated reaction system for continuously performing a plurality of optimization experiments to enable at least one optimal reaction parameter for a reaction to be identified, the reaction producing a desired product, comprising:

  • (a) a controller, said controller being configured to monitor and control the system while continuously performing a plurality of optimization experiments, such that during each of the plurality of optimization experiments, at least one of a plurality of reaction parameters controlled by the controller is changed according to a predefined protocol, the plurality of reaction parameters including at least the parameters of temperature and reactant concentration, the plurality of optimization experiments enabling optimal reaction parameters to be identified;

    (b) a reactant supply source for each reactant required for the reaction;

    (c) a solvent supply source coupled in fluid communication with each reactant supply source;

    (d) a dilution pump for each reactant, each dilution pump being coupled in fluid communication with a corresponding reactant supply source and with the solvent supply source for a corresponding reactant, and being logically coupled to the controller and operative to vary a concentration of a corresponding reactant using a solvent;

    (e) a reaction module having an inlet coupled in fluid communication with each reactant supply source and the solvent supply source to receive each reactant, and an outlet, the reaction module being operative to initiate the reaction of the reactants; and

    (f) at least one analytical unit coupled in fluid communication with the outlet and logically coupled with the controller, the analytical unit being configured to analyze the desired product, producing data for the plurality of optimization experiments used to determine at least one optimal reaction parameter.

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