Hemostatic compositions and methods for controlling bleeding

• US 7,101,862 B2
• Filed: 12/31/2002
• Issued: 09/05/2006
• Est. Priority Date: 12/31/2001
• Status: Expired due to Fees

• Current Assignee: Craig E. Lighty, International Manufacturing Center
• Original Assignee: Ares Laboratories, LLC
• Inventors: Cochrum, Kent C., Jemtrud, Susan
• Primary Examiner(s): Wilson, James O.
• Assistant Examiner(s): Khare, Devesh
• Application Number:
  US10/334,864
• Publication Number:
  US 20030175327A1
• Time in Patent Office: 1,344 Days
• Field of Search: 514/54, 514/57, 514/59, 514/60, 536/3, 536/56, 536/102, 536/112, 536/123.1, 536/124, 424/445, 424/422, 424/443, 424/488, 424/499
• US Class Current: 514/54
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/232 Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 33/08 Polysaccharides
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: C08L 1/26 Cellulose ethers
• CPC Class Codes: C08L 5/02 Dextran; Derivatives thereof
• CPC Class Codes: C08L 5/04 Alginic acid; Derivatives thereof

Abstract

The invention provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions typically include an article containing cellulose, e.g., cotton gauze, and a polysaccharide covalently linked to the cellulose, or a polysaccharide ionically cross-linked and in association with the article. Methods of making and using the hemostatic compositions are also provided.

Claims

1. A bandage consisting essentially of a hemostatic composition, said hemostatic composition comprising cellulose and dextran covalently linked to said cellulose.

2. The bandage of claim 1, wherein said dextran is in the form of covalently cross-linked beads.

3. The bandage of claim 1, wherein the molecular weight of said dextran ranges from about 10,000 to about 2,000,000 Daltons.

4. The bandage of claim 3, wherein the molecular weight of said dextran ranges from about 20,000 to about 100,000 Daltons.

5. The bandage of claim 1, wherein said covalently linked dextran has a molecular weight exclusion limit greater than about 30,000 Daltons.

6. The bandage of claim 1, wherein said cellulose is cotton.

7. The bandage of claim 6, wherein said cellulose is cotton gauze.

8. The bandage of claim 1, further comprising cross-linked alginate linked to said cellulose.

9. The bandage of claim 8, wherein said cross-linked alginate is covalently linked to said cellulose.

10. The bandage of claim 8, wherein said dextran is in the form of covalently cross-linked beads.

11. The bandage of claim 10, wherein said covalently cross-linked dextran beads comprise Ca2+.

12. A bandage comprising a hemostatic composition, said hemostatic composition comprising ionically linked dextran-alginate spheres covalently linked to cellulose.

13. The bandage of claim 12, wherein said ionically linked dextran-alginate spheres are linked ionically with Ca2+.

14. The bandage of claim 13, wherein said ionically linked dextran-alginate spheres are further cross-linked covalently.