Ion channel modulating compounds and uses thereof
First Claim
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1. A compound of formula (I), or a solvate or pharmaceutically acceptable salt thereof:
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Abstract
Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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11 Claims
- 1. A compound of formula (I), or a solvate or pharmaceutically acceptable salt thereof:
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10. A compound, or mixture comprising compounds, selected from the group consisting of:
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(+)-trans-[2-(4-morpholinyl)-1-(2-naphthenethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(2-naphthenethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(1-naphthenethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(1-naphthenethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(4-bromophenethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(4-bromophenethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-[2-(2-naphthoxy)ethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-[2-(2-naphthoxy)ethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-[2-(4-bromophenoxy)ethoxy]]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-[2-(4-bromophenoxy)ethoxy]]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(3,4-dimethoxyphenethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(3,4-dimethoxyphenethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(2-(benzo[b]thiophen-3-yl)ethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(2-(benzo[b]thiophen-3-yl)ethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(2-(benzo[b]thiophen-4-yl)ethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(2-(benzo[b]thiophen-4-yl)ethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(3-bromophenethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(3-bromophenethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(2-bromophenethoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(2-bromophenethoxy)]cyclohexane;(+)-trans-[2-(4-morpholinyl)-1-(3-(3,4-dimethoxyphenyl)-1-propoxy)]cyclohexane; (−
)-trans-[2-(4-morpholinyl)-1-(3-(3,4-dimethoxyphenyl)-1-propoxy)]cyclohexane;(1R,2R)/(1S,2S)-2-(4-morpholinyl)-1-(3,4-dichlorophenethoxy)cyclohexane; and (1R,2S)/(1S,2R) 2 (4morpholinyl)-1-[(2-trifluoromethyl)phenethoxy]cyclohexane; including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof; and
pharmaceutically acceptable salts thereof.
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Specification