Apparatus and method for reversal of myocardial remodeling with electrical stimulation
First Claim
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1. A method for cardiac pacing, comprising:
- measuring an intrinsic conduction delay between a stressed ventricular site and an earlier excited ventricular site during an intrinsic heartbeat referred to as a V—
V interval;
delivering pacing pulses to the stressed ventricular site in accordance with a programmed pacing mode, wherein the pacing pulses are delivered after an AV pacing delay interval following an atrial sense or pace which is set in accordance with the measured V—
V interval.
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Abstract
An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
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Citations
20 Claims
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1. A method for cardiac pacing, comprising:
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measuring an intrinsic conduction delay between a stressed ventricular site and an earlier excited ventricular site during an intrinsic heartbeat referred to as a V—
V interval;delivering pacing pulses to the stressed ventricular site in accordance with a programmed pacing mode, wherein the pacing pulses are delivered after an AV pacing delay interval following an atrial sense or pace which is set in accordance with the measured V—
V interval. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A cardiac rhythm management device, comprising:
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a plurality of sensing channels for sensing intrinsic cardiac activity; a pacing channel for delivering pacing pulses to a ventricular pacing site; a controller for controlling the delivery of pacing pulses; wherein the controller is programmed to measure an intrinsic conduction delay between a stressed ventricular site and an earlier excited ventricular site during an intrinsic heartbeat referred to as a V—
V interval; andwherein the controller is programmed to deliver pacing pulses to the stressed ventricular site in accordance with a programmed pacing mode, wherein the pacing pulses are delivered after an AV pacing delay interval following an atrial sense which is set in accordance with the measured V—
V interval. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification