System and method for high pressure delivery of gas-supersaturated fluids

• US 7,104,289 B2
• Filed: 08/30/2004
• Issued: 09/12/2006
• Est. Priority Date: 08/15/1997
• Status: Expired due to Fees

• Current Assignee: TherOx Incorporated (Asahi Kasei Corporation)
• Original Assignee: TherOx Incorporated (Asahi Kasei Corporation)
• Inventors: Gessert, James M., Daoud, Adib G.
• Primary Examiner(s): MAUST, TIMOTHY LEWIS
• Application Number:
  US10/929,918
• Publication Number:
  US 20050028883A1
• Time in Patent Office: 743 Days
• Field of Search: 141/2, 141/18, 141/21, 141/25, 141/27, 141/98, 141/285, 141/301, 604/23, 604/26, 604/151, 604/154, 222/309, 222/340
• US Class Current: 141/27
• CPC Class Codes: A61M 1/32 Oxygenators without membranes
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions

Abstract

A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a fluid to be gas-supersaturated and a drive assembly for delivering the fluid to a delivery site. The housing assembly comprises a cylinder and a piston which-may be advanced along the inner surface of the cylinder to pressurize and to deliver the fluid. To generate a gas-supersaturated fluid, the housing assembly is removed from the system housing, filled with a fluid, and gas is introduced at or slightly above the desired gas partial pressure into the cylinder. To deliver the gas-supersaturated fluid, the fluid assembly is returned to the system housing and the drive assembly advances the piston to increase the hydrostatic pressure to the desired delivery pressure and, after opening a valve, to deliver the gas-supersaturated fluid at the desired high delivery pressure to a delivery site.

Claims

1. A system for delivering fluid to a delivery site comprising:

a fluid assembly comprising a receptacle for containing fluid and a piston adapted to travel within the receptacle, the piston comprising;

a seal adapted to seal the piston within the receptacle;

a port extending through the piston; and

a valve operatively arranged relative to the port to permit introduction of the fluid into the receptacle;

a drive assembly positioned adjacent the fluid assembly to advance the piston within the receptacle to pressurize the fluid; and

a flow delivery assembly coupled to the fluid port of the receptacle to deliver the pressurized fluid to the delivery site.

2. The system, as set forth in claim 1, wherein the valve comprises a check valve, the check valve having a valve seat, a ball, and a spring, the spring biasing the ball toward the valve seat.

3. The system, as set forth in claim 2, wherein the piston comprises an actuator being moveable in a first direction to move the ball away from the valve scat and being moveable in a second direction to move the ball into contact with the valve seat.

4. The system, as set forth in claim 3, wherein the fluid may be introduced into the receptacle through the piston when the actuator moves the ball in the first direction.

5. The system, as set forth in claim 2, wherein the fluid maybe introduced into the receptacle through the piston when the fluid overcomes the force of the spring to move the ball away from the valve seat.

6. The system, as set forth in claim 1, wherein the port is adapted to accept a cannula for the introduction of the fluid into the receptacle.

7. The system, as set forth in claim 1, wherein the receptacle comprises a piston cap which retains the piston within the receptacle.

8. The system, as set forth in claim 2, wherein the check valve prevents the fluid from escaping from the receptacle.

9. The system, as set forth in claim 1, wherein the seal comprises a high pressure seal disposed about a peripheral portion of the piston.

10. The system, as set forth in claim 1, wherein the drive assembly comprises a drive screw and a piston pusher, the piston pusher being disposed on the drive screw and being moveable along the drive screw and into contact with the piston in response to rotation of the drive screw.

11. The system, as set forth in claim 10, wherein the drive assembly comprises a motor being drivingly coupled to a gear box, the gear box being operably coupled to the drive screw to cause rotation of the drive screw.

12. The system, as set forth in claim 1, comprising a housing, the fluid assembly and the drive assembly being disposed in the housing.

13. The system, as set forth in claim 1, comprising a display coupled to the system to indicate given operating parameters to a user.

14. The system, as set forth in claim 1, comprising a control panel coupled to the system to input given operating parameters into the system.

15. The system, as set forth in claim 1, wherein the flow delivery assembly comprises a manifold having a control valve in fluid communication with the fluid port, the valve being in fluid communication to a fluid delivery device which delivers the pressurized fluid to the delivery site.