Base isolated nebulizing device and methods

• US 7,104,463 B2
• Filed: 10/06/2005
• Issued: 09/12/2006
• Est. Priority Date: 05/02/2001
• Status: Expired due to Term

• Current Assignee: Novartis Pharma AG (Novartis Ag)
• Original Assignee: Aerogen, Inc. (Nektar Therapeutics)
• Inventors: Litherland, Craig M., Maxwell, Joe, Loeffler, Joseph
• Primary Examiner(s): Ganey, Steven J.
• Application Number:
  US11/246,028
• Publication Number:
  US 20060086819A1
• Time in Patent Office: 341 Days
• Field of Search: 239/4, 239/102.1, 239/102.2, 239/338, 239/548, 239/552, 239/596
• US Class Current: 239/4
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: B05B 17/0646 Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto

Abstract

An aerosol generator comprises a vibratable member having a front, a rear, an outer periphery and a plurality of apertures extending between the front and the rear. A support element is disposed about the outer periphery of the vibratable member, and a vibratable element is coupled to the support element. The vibratable element is configured to vibrate the vibratable member at ultrasonic frequencies. An isolating structure is coupled to the support element and is configured to couple the aerosol generator to a support structure. The isolating structure has a mechanical vibrational impedance that is sufficient to substantially vibrationally isolate the aerosol generator from the support structure.

Claims

1. An aerosol generator system comprising:

an aerosol generator comprising a vibratable member having a front, a rear and a plurality of apertures extending between the front and the rear, wherein the aerosol generator is configured to produce liquid droplets when operated at a certain vibrational frequency;

an isolating structure operably coupled to the aerosol generator and that is configured to couple the aerosol generator to a support structure, wherein the isolating structure comprises means for substantially vibrationally isolating the aerosol generator from the support structure.

2. An aerosol generator system as in claim 1, wherein the aerosol generator further comprises a support element disposed about an outer periphery of the vibratable member;

and a vibratable element coupled to the support element, the vibratable element being configured to vibrate the vibratable member at ultrasonic frequencies, and wherein the isolating structure and the support element are integrally formed together.

3. An aerosol generator system as in claim 2, wherein the means for substantially vibrationally isolating the aerosol generator from the support structure has resonant frequencies that are outside of an operating frequency range of the aerosol generator.

4. An aerosol generator system as in claim 3, wherein the operating frequency range is about 50 kHz to about 250 kHz.

5. An aerosolization generator system as in claim 2, wherein the support element comprises a disc member having a central aperture across which the vibratable member is positioned.

6. An aerosol generator as in claim 1, wherein the means for substantially vibrationally isolating the aerosol generator from the support structure comprises a plurality of arms extending from the support element.

7. An aerosol generator system as in claim 1, wherein the arms have a contoured shape.

8. An aerosol generator system as in claim 1, wherein the means for substantially vibrationally isolating the aerosol generator from the support structure is configured such that the ratio of forces transmitted to the support structure to forces at an outer edge of the support element is less than about 30%.

9. An aerosol generator system as in claim 8, wherein the ratio is less than about 20%.

10. An aerosol generator system as in claim 1, wherein the vibratable member has a center portion containing the apertures, wherein the center portion is dome shaped in geometry, and wherein the apertures taper from the rear to the front.

11. An aerosolization device comprising:

a housing; and

an aerosol generator disposed within the housing, the aerosol generator comprising a vibratable member having a front, a rear and a plurality of apertures extending between the front and the rear, wherein the vibratable member is configured to vibrate at ultrasonic frequencies, an isolating structure coupled to the support element, and operably connected to the housing, wherein the isolating structure is configured to substantially vibrationally isolate the aerosol generator from the housing; and

wherein the isolating structure comprises a plurality of arms extending from the aerosol generator.

12. A device as in claim 11, wherein the aerosol generator further comprises a support element disposed about an outer periphery of the vibratable member, a vibratable element coupled to the support element to vibrate the vibratable member, wherein the isolating structure and the support element are integrally formed together.

13. A device as in claim 12, wherein the isolating member is configured such that the ratio of forces transmitted to the support element to forces at an outer edge of the support element is less than about 30%.

14. A device as in claim 13, wherein the ratio is less than about 10%.

15. An aerosol generator as in claim 12, wherein the support element comprises a disc member having a central aperture across which the vibratable member is positioned.

16. A device as in claim 11, wherein the arms have a contoured shape.

17. A device as in claim 11, wherein the isolating structure has resonant frequencies that are outside of an operating frequency range of the aerosol generator.

18. A device as in claim 17, wherein the operating frequency range is about 50 kHz to about 250 kHz.

19. A device as in claim 11, wherein the vibratable member has a center portion containing the apertures, wherein the center portion is dome shaped in geometry, and wherein the apertures taper from the rear to the front.

20. A method for aerosolizing a liquid, the method comprising:

providing an aerosol generator comprising a vibratable member having a front, a rear, and a plurality of apertures extending between the front and the rear, and a vibratable element to vibrate the vibratable member;

supplying a liquid to the rear of the vibratable member; and

vibrating the vibratable member with the vibratable element to eject liquid droplets through the apertures while substantially vibrationally isolating the aerosol generator using a plurality of arms that are operably coupled to a support structure.

21. A method as in claim 20, further comprising vibrating the vibratable member at a frequency that is different than a resonant frequency of the isolating structure, and wherein the vibratable member is vibrated at a frequency in the range from about 50 kHz to about 250 kHz, and wherein the ratio of forces transmitted to the support structure to forces at an outer edge of the aerosol generator is less than about 30%.