Systems and methods for investigating intracranial pressure
First Claim
1. A method of assessing intracranial pressure related to at least one of hydrocephalus and dementia in a human or an animal, comprising the steps of:
- obtaining a first set of intracranial blood flow data;
generating at least two blood flow factor values from said first set of intracranial flow data;
correlating said at least two blood flow factor values; and
assessing intracranial pressure based at least on said correlated blood flow factor values;
wherein said at least two blood flow factor values include at least one of a mean flow velocity value, a systolic acceleration value, a pulsatility index value, a natural logarithm of systolic acceleration value, a peak systolic velocity value, an end diastolic velocity value, a peak systolic time value, an end diastolic time value, an acceleration/mean flow velocity index value, a velocity/impedance index value and an acceleration/impedance index value.
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Accused Products
Abstract
The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual'"'"'s overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.
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Citations
27 Claims
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1. A method of assessing intracranial pressure related to at least one of hydrocephalus and dementia in a human or an animal, comprising the steps of:
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obtaining a first set of intracranial blood flow data; generating at least two blood flow factor values from said first set of intracranial flow data; correlating said at least two blood flow factor values; and assessing intracranial pressure based at least on said correlated blood flow factor values; wherein said at least two blood flow factor values include at least one of a mean flow velocity value, a systolic acceleration value, a pulsatility index value, a natural logarithm of systolic acceleration value, a peak systolic velocity value, an end diastolic velocity value, a peak systolic time value, an end diastolic time value, an acceleration/mean flow velocity index value, a velocity/impedance index value and an acceleration/impedance index value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of assessing hydrocephalus in a human or an animal, comprising the steps of:
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obtaining a first set of intracranial blood flow data; generating at least two blood flow factor values from said first set of intracranial flow data; correlating said at least two blood flow factor values; and assessing intracranial pressure based at least on said correlated blood flow factor value; wherein said at least two blood flow factor values include at least one of a mean flow velocity value, a systolic acceleration value, a pulsatility index value, a natural logarithm of systolic acceleration value, a peak systolic velocity value, an end diastolic velocity value, a peak systolic time value, an end diastolic time value, an acceleration/mean flow velocity index value, a velocity/impedance index value and an acceleration/impedance index value.
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27. A method of assessing dementia in a human or an animal, comprising the steps of:
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obtaining a first set of intracranial blood flow data; generating at least two blood flow factor values from said first set of intracranial flow data; correlating said at least two blood flow factor values; and assessing intracranial pressure based at least on said correlated blood flow factor values; wherein said at least two blood flow factor values include at least one of a mean flow velocity value, a systolic acceleration value, a pulsatility index value, a natural logarithm of systolic acceleration value, a peak systolic velocity value, an end diastolic velocity value, a peak systolic time value, an end diastolic time value, an acceleration/mean flow velocity index value, a velocity/impedance index value and an acceleration/impedance index value.
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Specification