Method for achieving tissue changes in bone or bone-derived tissue

• US 7,105,011 B2
• Filed: 04/15/2003
• Issued: 09/12/2006
• Est. Priority Date: 08/18/2000
• Status: Expired due to Term

• Current Assignee: Nuortho Surgical Inc.
• Original Assignee: Map Technologies LLC (MIN AIK Technology Company Limited)
• Inventors: Auge, Wayne K. II
• Primary Examiner(s): ROLLINS, ROSILAND STACIE
• Application Number:
  US10/414,781
• Publication Number:
  US 20030175251A1
• Time in Patent Office: 1,246 Days
• Field of Search: 128/898, 606/213, 606/214, 606/8, 606/27, 606/28, 606/40, 607/88, 607 96-105
• US Class Current: 607/96
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/88 Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices A61B17/7074 takes precedence
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2018/00619 Welding
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/4644 Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material bone material A61F2/28; disintegrating or milling devices B02C
• CPC Class Codes: A61F 2002/2821 Bone stimulation by electromagnetic fields or electric current for enhancing ossification
• CPC Class Codes: A61F 2002/30451 soldered or brazed or welded
• CPC Class Codes: A61F 2002/30622 Implant for fusing a joint or bone material
• CPC Class Codes: A61F 2002/30668 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61F 2002/4635 using minimally invasive surgery
• CPC Class Codes: A61F 2002/4649 Bone graft or bone dowel harvest sites
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2250/0001 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61L 24/0005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/3691 characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation

Abstract

A method of achieving tissue changes in bone or bone-derived organic tissue, in which method bone or bone-derived organic tissue is provided, an interfacing agent is applied to the bone or bone-derived organic tissue, and electromagnetic energy is applied to the interfacing agent. The interfacing agent can include collagen, preferably bone-derived collagen, and a therapeutic agent. In a related embodiment, a method of treating bone tissue is provided wherein a bioactive interfacing agent is placed between the bone segments of the bone tissue to be treated.

Claims

1. A method of achieving tissue changes in bone or bone-derived organic tissue comprising the steps of:

providing bone or bone-derived organic tissue in an electrically conductive medium;

applying an interfacing agent to the bone or bone-derived organic tissue; and

applying electromagnetic energy to the interfacing agent while the bone or bone-derived organic tissue is in the electrically conductive medium.

2. The method of claim 1 wherein the applying step comprises applying radio frequency energy.

3. The method of claim 1 wherein the interfacing agent comprises collagen and a therapeutic agent.

4. The method of claim 3, wherein the collagen is bone-derived collagen.

5. The method of claim 4, wherein the source of bone-derived collagen is acid treated bone-derived graft material.

6. The method of claim 5, wherein the acid treated bone-derived graft material is derived from autologous bone of the patient to be treated.

7. The method of claim 3, wherein the collagen is made by synthetic or recombinant means.

8. The method of claim 3, wherein the therapeutic agent comprises hydroxyapetite.

9. The method of claim 3, wherein the therapeutic agent comprises an osteogenic protein.

10. The method of claim 3, wherein the therapeutic agent comprises a growth factor.

11. The method of claim 1, wherein the interfacing agent comprises one or more members from the group consisting of osteoconductive, osteoinductive, and osteogenic substances or agents.

12. The method of claim 1, wherein the interfacing agent comprises a hydrophobic, lipophilic carrier paste-gel-like material.

13. The method of claim 1, wherein the interfacing agent comprises heat releasing microspheres.