Processing set and methods for processing and treating a biological fluid

• US 7,105,093 B2
• Filed: 10/08/2002
• Issued: 09/12/2006
• Est. Priority Date: 06/03/1999
• Status: Expired due to Term

• Current Assignee: Cerus Corporation, Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Baxter International Inc., Cerus Corporation
• Inventors: Mohiuddin, Mahmood, Metzel, Peyton S., de Gheldere, Serge, Clarke, Michael S., Hei, Derek J., Cimino, George D.
• Primary Examiner(s): Cintins, Ivars C.
• Application Number:
  US10/267,566
• Publication Number:
  US 20030085173A1
• Time in Patent Office: 1,435 Days
• Field of Search: 210/668, 210/691, 210/748, 422/24, 422/101
• US Class Current: 210/668
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61L 2/0023 Heat
• CPC Class Codes: A61L 2/0035 Gamma radiation
• CPC Class Codes: A61L 2/0047 Ultraviolet radiation
• CPC Class Codes: A61L 2/007 Particle radiation, e.g. electron-beam, alpha or beta radiation
• CPC Class Codes: A61L 2/0082 using chemical substances
• CPC Class Codes: A61L 2/24 Apparatus using programmed or automatic operation
• CPC Class Codes: A61L 2/26 Accessories or devices or components used for biocidal treatment
• CPC Class Codes: A61L 2202/122 Chambers for sterilisation
• CPC Class Codes: A61L 2202/14 Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
• CPC Class Codes: A61L 2202/22 Blood or products thereof
• CPC Class Codes: A61M 1/0218 with filters
• CPC Class Codes: A61M 1/0236 with sampling means, e.g. sample bag or sampling port
• CPC Class Codes: A61M 1/0277 Frames constraining or supporting bags, e.g. during freezing
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3686 by removing photoactive agents after irradiation
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor

Abstract

Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Claims

1. A method for providing a substantially pathogen-free biological fluid comprising:

providing a source container of a collected biological fluid;

providing a sterile disposable fluid processing set comprising at least a treating container integrally pre-connected to a container including a photochemical agent, wherein said treating container is pre-connected to a container housing an adsorbent material with an openable flow path therebetween, wherein said container housing said adsorbent material is integrally preconnected to a storage container with an openable flow path therebetween;

connecting said source container to said container including said photochemical agent in a sterile manner;

establishing fluid communication between said source container and said container including said photochemical agent;

transferring said biological fluid from said source container to said treating container through said container including said photochemical agent to combine said photochemical agent with said biological fluid;

providing a light source capable of providing light sufficient to activate said photochemical agent;

treating said biological fluid in said treating container by contacting said biological fluid with light from said light source;

opening said flow path between said treating container and said container housing said adsorbent material;

contacting said biological fluid with said adsorbent material;

passing said biological fluid from said container housing said adsorbent material through a filter material located between said adsorbent material and said storage container and;

collecting said biological fluid in said storage container.

2. The method of claim 1 comprising detaching said source container from said treating container after said transferring of said biological fluid from said source container.

3. The method of claim 1 comprising detaching said source container and said container that included said photochemical agent from the remainder of said disposable processing set after said transferring.

4. The method of claim 1 comprising detaching said treating container from the remainder of said disposable processing set.

5. The method of claim 1 comprising contacting said biological fluid with said adsorbent material for between approximately 30 seconds and 7 days.

6. The method of claim 1 comprising detaching said container housing said adsorbent material from said storage container.

7. The method of claim 1 further comprising expressing air from said storage container after said collecting step.

8. The method of claim 1 comprising indicating on said storage container the status of said treatment of fluid.

9. The method of claim 1 comprising agitating said container with said adsorbent material disposed therein during said contacting step.

10. The method of claim 1 further comprising:

providing a holder for at least said container housing said adsorbent material;

holding said container housing said absorbent material with or within said holder during said treating step while maintaining integral connection with said treating container.

11. The method of claim 10 comprising:

holding said storage container with or within said holder during said treating step while maintaining integral connection with said treating container.

12. The method of claim 1 wherein said contacting step comprises contacting said biological fluid with a particulate adsorbent material.