Retentate chromatography and protein chip arrays with applications in biology and medicine
First Claim
1. A probe comprising substrate in the shape of a plate or a strip having a flat surface and an adsorbent covalently bound to the surface, the adsorbent having a binding characteristic for binding an analyte, wherein the binding characteristic varies in a continuous gradient along one or more linear axes of the probe, wherein the probe is removably insertable into a laser desorption/ionization mass spectrometer.
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Abstract
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
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Citations
9 Claims
- 1. A probe comprising substrate in the shape of a plate or a strip having a flat surface and an adsorbent covalently bound to the surface, the adsorbent having a binding characteristic for binding an analyte, wherein the binding characteristic varies in a continuous gradient along one or more linear axes of the probe, wherein the probe is removably insertable into a laser desorption/ionization mass spectrometer.
Specification