Compositions and methods using sub-PPM combinations of polyquaternium-1 and high molecular weight PHMB
First Claim
1. A multi-purpose solution for contact lens care comprising:
- an aqueous liquid medium; and
an antimicrobial component, the antimicrobial component comprising from about 0.000005 to about 0.00009 w/v % polyquatemium-1 and from about 0.000005 to about 0.00009 w/v % high molecular weight PHMB, wherein the PHMB has a number average molecular weight of from about 4000 to about 45,000.
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Accused Products
Abstract
Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability, with minimal, if any, corneal epithelial punctate fluorescein staining. Such solutions may include an aqueous liquid medium; an antimicrobial component comprising polyquarternium-1 and a hexamethylene biguanide polymer having a number average molecular weight in the range of from about 4,000 to about 45,000; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a buffer component in an effective amount; a viscosity-inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
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Citations
19 Claims
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1. A multi-purpose solution for contact lens care comprising:
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an aqueous liquid medium; and an antimicrobial component, the antimicrobial component comprising from about 0.000005 to about 0.00009 w/v % polyquatemium-1 and from about 0.000005 to about 0.00009 w/v % high molecular weight PHMB, wherein the PHMB has a number average molecular weight of from about 4000 to about 45,000. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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- 12. A method for disinfecting a contact lens comprising contacting the lens with an aqueous solution comprising from about 0.000005 to about 0.00009 w/v % polyquaternium-1 and from about 0.000005 to about 0.00009 w/v % high molecular weight PHMB, wherein the PHMB has a number average molecular weight of from about 4000 to about 45,000.
Specification