N4-acylcytosine nucleosides for treatment of viral infections
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Abstract
The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration of N4-acyl-2′,3′-dideoxy-5-fluorocytidine or N4-acyl-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine, and pharmaceutically acceptable salts, prodrugs, and other derivatives thereof.
11 Citations
36 Claims
- 1. A compound of the following formula:
-
13. A compound selected from the following, or its pharmaceutically acceptable salt:
β
-D-2′
,3′
-didehydro-2′
,3′
-dideoxy-5-fluoro-N4-(4-iodobenzoyl)cytidine of the structure;- View Dependent Claims (14, 15, 16, 17, 21, 22, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
-
35. A method for the treatment of a host infected with HIV which comprises administering to said host an effective amount of β
- -D-2′
,3′
-didehydro-2′
,3′
-dideoxy-5-fluoro-N4-(3-nitrobenzoyl)cytidine or a pharmaceutically acceptable salt thereof.
- -D-2′
-
36. A method for the treatment of a host infected with HBV which comprises administering to said host an effective amount of β
- -D-2′
,3′
-didehydro-2′
,3′
-dideoxy-5-fluoro-N4-(3-nitrobenzoyl)cytidine or a pharmaceutically acceptable salt thereof.
- -D-2′
Specification