Electrospray emitter for microfluidic channel
First Claim
1. An electrospray device comprising;
- a chip having a microchannel extending to an edge of the chip;
a cover; and
an emitter film having a polygonal tip sandwiched between the chip and the cover such that the polygonal tip extends from such edge of the chip.
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Accused Products
Abstract
An electrospray ionization device incorporates a shaped thin film with a microfluidic channel. The device may be interfaced to a time-of-flight mass spectrometer (TFOMS). In one embodiment, the shaped thin film has a polygonal-shaped or triangle-shaped thin polymer tip formed by lithography and etching. The microfluidic channel is approximately 20 micrometer wide and 10 micrometers deep, and embossed in a substrate using a silicon master. The shaped thin film is aligned with the channel and bonded between the channel substrate and a flat plate to create a microfluidic channel with a wicking tip protruding from the end of the channel. Application of a high voltage at one end of the channel creates an electrospray from the tip, which is provided to the TFOMS.
182 Citations
58 Claims
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1. An electrospray device comprising;
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a chip having a microchannel extending to an edge of the chip;
a cover; and
an emitter film having a polygonal tip sandwiched between the chip and the cover such that the polygonal tip extends from such edge of the chip. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An electrospray device comprising:
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a chip having a microchannel with a first end extending to an edge of the chip;
a reservoir coupled to the microchannel;
a cover;
an emitter film haging a polygonal tip sandwiched betweenthe chip and the cover such that the polygonal tip extends from such edge of the chip; and
a power supply coupled to the reservoir. - View Dependent Claims (16, 17, 18, 19)
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20. An electrospray device comprising:
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a chi having a microchannel with a first end extending to an edge of the chip;
a reservoir coupled to the microchannel;
a cover;
an emitter film having a polygonal tip sandwiched between the chip and the cover such that the polygonal tip extends from such edge of the chip;
a power suply coupled to the reservoir; and
a counter electrode positioned a desired distance from the polygonal tip wherein a voltage across the power supply and counter electrode causes a Taylor cone of fluid from the channel to form on the tip. - View Dependent Claims (21)
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22. A method of makiong an electrospray device, the method comprising:
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forming a microchannel on a substrate running to an edge of the substrate;
obtaining a thin filmemitter having a body portion with a polygonal tip on an edge of the body portion;
bonding the substrated and a cover with at least part of the body portion of thin film emitter between the substrate and cover such that the tip extends from the channel at the end of the edge of the substrate. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29)
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30. An electrospray device comprising:
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a chip having a covered microfluidic structure that delivers fluid to an edge of the chip;
and a planar emitter having a tip coupled to the edge of the chip and extending therefrom, wherein the tip has anapex shaped to facilitate formation of a Taylor cone from fluid delivered to the edge of the chip. - View Dependent Claims (31, 32, 33, 34, 36, 37, 38)
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35. A microfluidic chip comprising:
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a top chip portion that is formed with at least one microchannel extending to an edge of the top chip portion;
a bottom chip portion coupled to the top chip portion; and
an electrospray emitter found as a single integrated piece with the bottom chip portion, wherein the electrospray emitter extends from the ege of the top chip portion for directing an electrospray from the microfluidic chip. - View Dependent Claims (39, 40, 41, 42, 44)
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43. An electrospray ionization device and mass spectrometer interface comprising:
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a covered microfluidic structure formed with a reservoir in fluid communication with a microchannel that delivers fluid to an exit side of the microfluidic structure; and
an electrospray emitter extending from the edge of the microfluidic structure that is formed as a single integrated piece with at least a portion of the microfluidic structure;
a mass spectrometer having an orifice for receiving and electrospray from the emitter; and
a power supply system connected to the reservoir and a counter electrode positioned substantially adjacent to the emitter for applying a voltage to emit at least a portion of the electrospray from the emitter into the orifice of the mass spectrometer. - View Dependent Claims (45, 46)
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47. An electrospray device comprising:
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a covered microfluidic structure formed with a micrchannel that delivers fluid to a selected surface of the microfluidic structure; and
a wicking tip extending from the selected surface of the microfluidic structure that is formed as a single integrated place with at least a portion of the microfluidic structure, wherein the tip is configured with a predefined shape to facilitate formation of a Taylo cone when fluid is sprayed therefrom. - View Dependent Claims (48, 49)
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50. A device comprising:
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a chip having a microchannel extending to an edge of the chip;
a cover; and
an electrospray emitter film having an apex, wherein the electrospray emitter film is sandwiched between the chip and the cover such that the apex extends from the edge of the chip. - View Dependent Claims (51, 52, 53)
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54. A device comprising:
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a chip having a microchannel extending to an edge of the chip;
a cover; and
emitter means extending from the edge of the chip and coupled to the microchannel for emitting an electrospray from fluid flowing through the microchannel. - View Dependent Claims (55, 56)
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57. A device comprising:
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a chip having multiple microchannels extending to an edge of the chip;
a cover; and
a plurality of electrospray emitter films, each having an apex, wherein the electrospray emitter films are disposed between the chip and the cover such that each apex extends from a microchannel at the edge of the chip. - View Dependent Claims (58)
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Specification