Use of activation and recovery times and dispersions to monitor heart failure status and arrhythmia risk
First Claim
1. A method for monitoring a heart, comprising:
- detecting a plurality of localized electrogram (EGM) signals associated with electrical activity of a heart at a plurality of sensing sites, wherein a plurality of addressable electrodes produce a plurality of sensing vectors at the plurality of sensing sites within a single chamber of the heart;
measuring an activation time for a given cardiac cycle for each of the detected plurality of localized EGM signals;
measuring a recovery time for the given cardiac cycle from each of the detected plurality of localized EGM signals;
calculating an activation recovery interval as the difference between the activation time and the recovery time for each said detected plurality of localized EGM signals; and
calculating at least a one of;
a dispersion of activation time, a recovery time, an activation recovery interval based on the detected plurality of localized EGM signals.
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Accused Products
Abstract
A system and method for monitoring electrical dispersion of the heart is provided including an implantable medical device and associated electrode system for sensing cardiac signals from a combination of two or more local and/or global EGM sensing vectors and/or subcutaneous ECG sensing vectors. Activation and recovery times and the activation-recovery intervals are measured from a selected cardiac cycle for each sensing vector. Dispersion is determined as the differences between activation times, recovery times and/or ARIs measured from each of the sensing vectors. An increase in dispersion indicates a worsening of heart failure and/or an increased risk of arrhythmias. Accordingly, a cardiac therapy may be delivered or adjusted in response to a detected increase in dispersion.
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Citations
23 Claims
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1. A method for monitoring a heart, comprising:
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detecting a plurality of localized electrogram (EGM) signals associated with electrical activity of a heart at a plurality of sensing sites, wherein a plurality of addressable electrodes produce a plurality of sensing vectors at the plurality of sensing sites within a single chamber of the heart; measuring an activation time for a given cardiac cycle for each of the detected plurality of localized EGM signals; measuring a recovery time for the given cardiac cycle from each of the detected plurality of localized EGM signals; calculating an activation recovery interval as the difference between the activation time and the recovery time for each said detected plurality of localized EGM signals; and calculating at least a one of;
a dispersion of activation time, a recovery time, an activation recovery interval based on the detected plurality of localized EGM signals. - View Dependent Claims (2, 3, 4, 5)
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6. An apparatus for monitoring a heart, comprising:
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means for detecting a plurality of localized electrogram (EGM) signals associated with electrical activity of a heart at a plurality of sensing sites, wherein a plurality of addressable electrodes produce a plurality of sensing vectors at the plurality of sensing sites disposed within a single chamber of the heart; means for measuring an activation time for a given cardiac cycle for each of the detected plurality of localized EGM signals; means for measuring a recovery time for the given cardiac cycle from each of the detected plurality of localized EGM signals; means for calculating an activation recovery interval as the difference between the activation time and the recovery time for each said detected plurality of localized EGM signals; and means for calculating at least a one of;
a dispersion of activation time, a recovery time, an activation recovery interval. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A computer readable medium for storing instructions providing control signals via a computer processor, comprising:
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instructions for detecting a plurality of localized electrogram (EGM) signals associated with electrical activity of a heart at a plurality of sensing sites, wherein a plurality of addressable electrodes produce a plurality of sensing vectors at the plurality of sensing sites disposed within a single chamber of the heart; instructions for measuring an activation time for a given cardiac cycle for each of the detected plurality of localized EGM signals; instructions for measuring a recovery time for the given cardiac cycle from each of the detected plurality of localized EGM signals; instructions for calculating an activation recovery interval as the difference between the activation time and the recovery time for each said detected plurality of localized EGM signals; and instructions for calculating at least a one of;
a dispersion of activation time, a recovery time, an activation recovery interval. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23)
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Specification