Device for and method of rapid noninvasive measurement of parameters of diastolic function of left ventricle and automated evaluation of the measured profile of left ventricular function at rest and with exercise
First Claim
1. A method of rapid noninvasive measurement of parameters of diastolic function of left ventricle and automated evaluation of the measured profile of left ventricular function at rest and with exercise, wherein:
- the patient performs an isometric exercise trough an external device,an external pressure transducer and heart sounds microphone are applied as noninvasive sensor units on the thoracic wall to obtain a noninvasive left ventricular pressure mirroring curve and simultaneously the heart sounds; and
and an external utilization unit determines and calculates characteristic diastolic parameters derived from the pressocardiographic curve and phonocardiogram at rest, during and after exercise, converts each said pressocardiogram into a digital waveform in the time domain, and automatically categorizes the mentioned characteristic parameters based on exact categorization criteria for defining at least one of the following differentialforms of diastolic dysfunction of left ventricle in human beings;
a) a diastolic Hypertensive differential formb) a diastolic Coronary differential formc) diastolic Cardiomyopathic differential formd) a diastolic Congestive differential forme) a diastolic Advanced differential form.
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Abstract
In a method of noninvasive measurement of parameters of diastolic function of left ventricle and automated evaluation of the measured profile at rest and with exercise, a patient performs an isometric exercise. An external pressure sensor and heart sounds microphone are applied in a non-invasive manner on the thoracic wall to obtain a left ventricular pressure mirroring curve (pressocardiogram) and simultaneously the heart sounds (phonocardiogram). An external unit determines and calculates characteristic diastolic parameters derived from the pressocardiographic curve and phonocardiogram at rest, during and after exercise, converts each said pressocardiogram into a digital waveform in the time domain, and automatically categorizes the mentioned characteristic parameters based on exact categorization criteria for defining several differentialforms of diastolic dysfunction of left ventricle in human beings.
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Citations
34 Claims
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1. A method of rapid noninvasive measurement of parameters of diastolic function of left ventricle and automated evaluation of the measured profile of left ventricular function at rest and with exercise, wherein:
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the patient performs an isometric exercise trough an external device, an external pressure transducer and heart sounds microphone are applied as noninvasive sensor units on the thoracic wall to obtain a noninvasive left ventricular pressure mirroring curve and simultaneously the heart sounds; and and an external utilization unit determines and calculates characteristic diastolic parameters derived from the pressocardiographic curve and phonocardiogram at rest, during and after exercise, converts each said pressocardiogram into a digital waveform in the time domain, and automatically categorizes the mentioned characteristic parameters based on exact categorization criteria for defining at least one of the following differentialforms of diastolic dysfunction of left ventricle in human beings; a) a diastolic Hypertensive differential form b) a diastolic Coronary differential form c) diastolic Cardiomyopathic differential form d) a diastolic Congestive differential form e) a diastolic Advanced differential form. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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9. The method of claim wherein said characteristic parameter TART will be included as a positivity criterion of HAT having the following upper normal limits:
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TART at rest or after exercise >
140 ms to 1≡
ms, preferably 159 ms;TART during exercise >
140 ms to 159 ms, preferably >
155 ms.
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23. A device for rapid noninvasive measurement of parameters of diastolic function of left ventricle and automated evaluation of the profile of left ventricular function at rest and with exercise, comprising:
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external pressure sensor and heart sounds microphone as noninvasive sensor units applicable on the thoracic wall for obtaining a noninvasive left ventricular pressure mirroring curve and simultaneously the heart sounds; an external device enabling the patient to perform an isometric exercise, and an external utilization unit for determining and calculating of characteristic diastolic parameters derived from the pressocardiographic curve and phonocardiogram at rest, during and after exercise, converting each said pressocardiogram into a digital waveform in the time domain, and automatically categorizing based on the mentioned characteristic parameters; whereby the utilization unit contains exact categorization criteria for defining at least one of the following differentialforms of diastolic dysfunction of left ventricle in human beings; a) a diastolic Hypertensive differential form; b) a diastolic Coronary differential form; c) a diastolic Cardiomyopathic differential form; d) a diastolic Congestive differential form; e) a diastolic Advanced differential form. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification