Diffuse optical tomography system and method of use

• US 7,107,116 B2
• Filed: 09/02/2003
• Issued: 09/12/2006
• Est. Priority Date: 03/29/1999
• Status: Expired due to Fees

• Current Assignee: Technest Holdings, Inc. (AccelPath, Inc.)
• Original Assignee: Genex Technologies Incorporated (AccelPath, Inc.)
• Inventors: Geng, Z. Jason
• Primary Examiner(s): Picard, Leo
• Assistant Examiner(s): Rapp, Chad
• Application Number:
  US10/654,225
• Publication Number:
  US 20040087862A1
• Time in Patent Office: 1,106 Days
• Field of Search: 700/110, 700/117, 700/166, 356/302, 356/305, 356/432, 600309-312, 600/321, 600/322, 600/328, 600/329, 600473-478
• US Class Current: 700/117
• CPC Class Codes: A61B 5/0064 Body surface scanning
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence

Abstract

An improved diffuse optical tomography system for in vivo non-contact imaging includes an illumination source for illuminating a specimen, a spectrum source for projecting a spectrum onto the specimen, at least one sensor configured to capture the response of the specimen to the illumination and to the projection of said spectrum.

Claims

1. An improved diffuse optical tomography system for in vivo non-contact imaging, comprising:

an illumination source for illuminating a specimen;

a spectrum source for projecting a spectrum onto said specimen; and

at least one sensor configured to capture a response of said specimen to said illumination and said projection of said spectrum;

wherein said illumination source comprises a plurality of lasers, wherein said plurality of lasers comprises four lasers, wherein said lasers are each configured to generate wavelengths between approximately 650nm and 800nm;

further comprising a mirror assembly configured to project light from said lasers as a single beam onto said specimen.

2. The system of claim 1, wherein said mirror assembly comprises a plurality of motors configured to manipulate said mirror assembly to direct said single beam onto any desired point on said specimen.

3. An improved diffuse optical tomography system for in vivo non-contact imaging, comprising:

an illumination source for illuminating a specimen;

a spectrum source for projecting a spectrum onto said specimen;

at least one sensor configured to capture a response of said specimen to said illumination and said projection of said spectrum; and

a processor-based device configured to process data acquired by said sensor, said device producing and combining tomography data based on sensing of said illumination source and three-dimensional data of a surface of said specimen based on sensing of said spectrum source.

4. An improved diffuse optical tomography system for in vivo non-contact imaging, comprising:

an illumination source for illuminating a specimen;

a spectrum source for projecting a spectrum onto said specimen;

at least one sensor configured to capture a response of said specimen to said illumination and said projection of said spectrum; and

a processor-based device configured to control said illumination source, said spectrum source and a minor assembly for directing light from said illumination source onto said specimen.

5. An improved diffuse optical tomography system for in vivo non-contact imaging, comprising:

an illumination source for illuminating a specimen;

a spectrum source for projecting a spatially varying wavelength spectrum onto said specimen; and

a sensor assembly configured to capture responses to said illumination and said projection of said spectrum;

wherein said illumination source comprises four lasers, wherein said lasers are each configured to generate light between approximately 650nm and 800nm in wavelength; and

further comprising a mirror assembly configured to project said light from said lasers as a single beam onto said specimen.

6. The system of claim 5, wherein said minor assembly comprises a plurality of motors configured to manipulate said minor assembly to direct said single beam onto a pre-determined location on said specimen.

7. An improved diffuse optical tomography system for in vivo non-contact imaging, comprising:

an illumination source for illuminating a specimen;

a spectrum source for projecting a spatially varying wavelength spectrum onto said specimen;

a sensor assembly configured to capture responses to said illumination and said projection of said spectrum; and

a processor-based device configured to control said illumination source and said spectrum source.

8. An improved DOT imaging system, comprising:

means for capturing three-dimensional boundary characteristics of a surface of a specimen; and

means for substantially simultaneously capturing DOT characteristics.

9. The system of claim 8, wherein said means for capturing three-dimensional boundary characteristics and said means for substantially simultaneous capturing DOT characteristics comprise independent sensor means.

10. The system of claim 8, wherein said means for capturing three-dimensional boundary characteristics and said means for substantially simultaneous capturing DOT characteristics comprise a shared sensor assembly.

11. The system of claim 8, further comprising means for processing said captured characteristics.

12. The system of claim 8, wherein said means for capturing three-dimensional boundary characteristics comprises a laser-scanner.