Delivery of muscle relaxants through an inhalation route
First Claim
1. A condensation aerosol for delivery of a drug selected from the group consisting of quinine, chlorzoxazone, carisprodol and cyclobenzaprine, wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.
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Abstract
The present invention relates to the delivery of muscle relaxants through an inhalation route. Specifically, it relates to aerosols containing muscle relaxants that are used in inhalation therapy. In a method aspect of the present invention, a muscle relaxant is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a muscle relaxant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% muscle relaxant degradation products. In a kit aspect of the present invention, a kit for delivering a muscle relaxant through an inhalation route is provided which comprises: a) a coating of a muscle relaxant and b) a device for dispensing said coating a muscle relaxant as a condensation aerosol.
199 Citations
34 Claims
- 1. A condensation aerosol for delivery of a drug selected from the group consisting of quinine, chlorzoxazone, carisprodol and cyclobenzaprine, wherein the condensation aerosol is formed by heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and condensing the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.
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4. A method of producing a drug selected from the group consisting of quinine, chlorzoxazone, carisprodol and cyclobenzaprine in an aerosol form comprising:
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a. heating a thin layer containing the drug, on a solid support, to produce a vapor of the drug, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns. - View Dependent Claims (5, 6, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A condensation aerosol for delivery of quinine, wherein the condensation aerosol is formed by heating a thin layer containing quinine, on a solid support, to produce a vapor of quinine, and condensing the vapor to form a condensation aerosol characterized by less than 5% quinine degradation products by weight, and an MMAD of about 0.2 to 3 microns.
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28. A condensation aerosol for delivery of chlorzoxazone, wherein the condensation aerosol is formed by heating a thin layer containing chlorzoxazone, on a solid support, to produce a vapor of chlorzoxazone, and condensing the vapor to form a condensation aerosol characterized by less than 5% chlorzoxazone degradation products by weight, and an MMAD of 0.2 to 3 microns.
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29. A condensation aerosol for delivery of carisiprodol, wherein the condensation aerosol is formed by heating a thin layer containing carisiprodol, on a solid support, to produce a vapor of carisiprodol, and condensing the vapor to form a condensation aerosol characterized by less than 5% carisiprodol degradation products by weight, and an MMAD of 0.2 to 3 microns.
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30. A condensation aerosol for delivery of cyclobenzaprine, wherein the condensation aerosol is formed by heating a thin layer containing cyclobenzaprine, on a solid support, to produce a vapor of cyclobenzaprine, and condensing the vapor to form a condensation aerosol characterized by less than 5% cyclobenzaprine degradation products by weight, and an MMAD of 0.2 to 3 microns.
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31. A method of producing quinine in an aerosol form comprising:
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a. heating a thin layer containing quinine, on a solid support, to produce a vapor of quinine, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% quinine degradation products by weight, and an MMAD of 0.2 to 3microns.
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32. A method of producing chlorzoxazone in an aerosol form comprising:
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a. heating a thin layer containing chlorzoxazone, on a solid support, to produce a vapor of chlorzoxazone, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% chlorzoxazone degradation products by weight, and an MMAD of 0.2 to 3 microns.
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33. A method of producing carisiprodol in an aerosol form comprising:
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a. heating a thin layer containing carisiprodol, on a solid support, to produce a vapor of carisiprodol, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% carisiprodol degradation products by weight, and an MMAD of 0.2 to 3 microns.
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34. A method of producing cyclobenzaprine in an aerosol form comprising:
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a. heating a thin layer containing cyclobenzaprine, on a solid support, to produce a vapor of cyclobenzaprine, and b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 5% cyclobenzaprine degradation products by weight, and an MMAD of about 0.2 to 3 microns.
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Specification