Multiple ion sources involving atmospheric pressure photoionization
First Claim
1. A monitor that can detect a plurality of trace molecules, comprising:
- a housing with an ionizing chamber that is approximately at one atmosphere and a single sample inlet that allows a sample to flow into said ionizing chamber;
a photoionizer that is coupled to said ionizing chamber and can be activated and deactivated to ionize the sample;
an electrospray ionizer coupled to said ionizing chamber and can be activated and deactivated to ionize the sample;
a switch that activates and deactivates said photoionizer and said electrospray ionizer to control different modes of operation; and
,a detector that is coupled to said ionizing chamber.
7 Assignments
0 Petitions
Accused Products
Abstract
A monitor that has multiple ioniziation sources that can be switched between different modes. The monitor may have an electrostatic ionizer and a photoionizer that ionize at approximately atmospheric pressure. Activation of the ionizers is controlled by a switch. The switch can activate the ionizers in accordance with a plurality of modes. For example, the switch may create modes where the ionizers are activated sequentially or simultaneously. The monitor may further have a chemical ionizer that is controlled by the switch to activate in a plurality of modes. The modes may be switched to detect different trace molecules of a sample loaded into an ionization chamber. The ionizers are preferably located at orthogonal angles relative to each other.
74 Citations
82 Claims
-
1. A monitor that can detect a plurality of trace molecules, comprising:
-
a housing with an ionizing chamber that is approximately at one atmosphere and a single sample inlet that allows a sample to flow into said ionizing chamber; a photoionizer that is coupled to said ionizing chamber and can be activated and deactivated to ionize the sample; an electrospray ionizer coupled to said ionizing chamber and can be activated and deactivated to ionize the sample; a switch that activates and deactivates said photoionizer and said electrospray ionizer to control different modes of operation; and
,a detector that is coupled to said ionizing chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
21. A monitor that can detect a plurality of trace molecules, comprising:
-
a housing with an ionizing chamber that is approximately at one atmosphere and a single sample inlet that allows a sample to flow into said ionizing chamber; a photoionizer that is coupled to said ionizing chamber and can be activated and deactivated to ionize the sample; an electrospray ionizer coupled to said ionizing chamber and can be activated and deactivated to ionize the sample; switch means for controlling the operation of said photoionizer and said electrospray ionizer to control different modes of operation; and
,a detector that is coupled to said ionizing chamber. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
-
-
41. A method for detecting a plurality of trace molecules, comprising:
-
introducing a sample into an ionizing chamber through a single sample inlet; ionizing a trace molecule within the sample with a photoionizer at approximately atmospheric pressure; ionizing a trace molecule within the sample with an electrospray ionizer at approximately atmospheric pressure; detecting the ionized trace molecules; and
,switching a mode of operation of the photoionizer and the electrospray ionizer by deactivating the photoionizer or the electrospray ionizer. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
-
-
55. A monitor that can detect a plurality of trace molecules, comprising:
-
a housing with an ionizing chamber that is approximately at one atmosphere and a single sample inlet that allows a sample to flow into said ionizing chamber; a photoionizer that is coupled to said ionizing chamber and can be activated and deactivate to ionize the sample; a chemical ionizer coupled to said ionizing chamber and can be activated and deactivate to ionize the sample; a switch that controls the operation of said photoionizer and said chemical ionizer to control different modes of operation; and
,a detector that is coupled to said ionizing chamber. - View Dependent Claims (56, 57, 58, 59, 60, 61, 62, 63, 64)
-
-
65. A monitor that can detect a plurality of trace molecules, comprising:
-
a housing with an ionizing chamber that is approximately at one atmosphere and a single sample inlet that allows a sample to flow into said ionizing chamber; a photoionizer that is coupled to said ionizing chamber and can be activated and deactivated to ionize the sample; a chemical ionizer coupled to said ionizing chamber and can be activated and deactivated to ionize the sample; switch means for controlling the operation of said photoionizer and said chemical ionizer to control different modes of operation; and
,a detector that is coupled to said ionizing chamber. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72, 73, 74)
-
-
75. A method for detecting a plurality of trace molecules, comprising:
-
introducing a sample into an ionizing chamber through a single sample inlet; ionizing a trace molecule within the sample with a photoionizer at approximately atmospheric pressure; ionizing a trace molecule with the same with an chemical ionizer at approximately atmospheric pressure; detecting the ionized trace molecules; and
,switching a mode of operation of the photoionizer and the chemical ionizer by deactivating the photoionizer or the chemical ionizer. - View Dependent Claims (76, 77, 78, 79, 80, 81, 82)
-
Specification