Method for imaging an artery using a magnetic resonance contrast agent

• US 7,110,806 B2
• Filed: 08/26/2003
• Issued: 09/19/2006
• Est. Priority Date: 06/07/1993
• Status: Expired due to Fees

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): JUNG, WILLIAM C
• Application Number:
  US10/648,167
• Publication Number:
  US 20040068177A1
• Time in Patent Office: 1,120 Days
• Field of Search: None
• US Class Current: 600/420
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

Claims

1. A method of imaging a portion of the aorta of a patient using a magnetic resonance imaging system, the method comprising:

determining an arrival time of a test bolus in a region of interest;

correlating an administration of a magnetic resonance contrast agent with an acquisition of magnetic resonance image data, including image data which is representative of the center of k-space, using the arrival time of the test bolus;

administering the magnetic resonance contrast agent to the patient; and

acquiring the magnetic resonance image data using a 3D pulse sequence, wherein the image data which is representative of the center of k-space is acquired while the concentration of the contrast agent in the portion of the aorta is greater than a concentration of the contrast agent in veins and background tissue adjacent to the portion of the aorta.

2. The method of claim 1 wherein acquiring magnetic resonance image data further includes using a flip angle which is greater than about 30°

and less than or equal to about 90°

.

3. The method of claim 1 wherein acquiring magnetic resonance image data further includes using a TR which is less than about 10 milliseconds and a TE which is less than about 3 milliseconds.

4. The method of claim 1 wherein acquiring magnetic resonance image data further includes acquiring a substantial portion of the image data which is representative of the central portion of k-space while the patient suspends respiration.

5. The method of claim 1 further including correlating the acquisition of the image data which is representative of the center of k-space with the suspension of respiration by the patient.

6. The method of claim 1 further including imaging at least one renal artery of the patient by acquiring magnetic resonance image data, of a coronally oriented image volume including the renal artery wherein the image data being acquired while the concentration of the contrast agent in the renal artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

7. The method of claim 1 further including imaging at least one renal artery of the patient by acquiring magnetic resonance image data including image data which is representative of the center of k-space while the concentration of the contrast agent in the renal artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

8. The method of claim 7 wherein imaging at least one renal artery of the patient further includes collecting 3D phase contrast images.

9. The method of claim 1 wherein the image volume of the 3D pulse sequence includes at least one dimension which is greater than 25 cm.

10. The method of claim 1 further including:

collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the portion of the aorta by subtracting the image data of the pre-contrast image data set from the image data acquired while the concentration of the contrast agent in the portion of the aorta is greater than a concentration of the contrast agent in veins and background tissue adjacent to the portion of the aorta.

11. The method of claim 1 further including acquiring image data of the periphery of k-space while the concentration of the contrast agent in the aorta is greater than a concentration of the contrast agent in veins and background tissue adjacent to the aorta.

12. The method of claim 1 wherein calculating the arrival time of the contrast agent in a region of interest includes using an arrival time of a test bolus.

13. A method of imaging an artery of a patient using a magnetic resonance imaging system, the method comprising:

determining an arrival time of a magnetic resonance contrast agent in a region of interest wherein the region of interest includes the artery;

correlating an injection of the magnetic resonance contrast agent to the patient with a collection of magnetic resonance image data using the arrival time of the magnetic resonance contrast agent in the region of interest;

injecting the magnetic resonance contrast agent to the patient; and

collecting the magnetic resonance image data using a 3D pulse sequence, wherein collecting magnetic resonance image data includes collecting a substantial portion of the image data while the concentration of the contrast agent in the artery is greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

14. The method of claim 13 wherein the arrival time of the magnetic resonance contrast agent is an estimated arrival time.

15. The method of claim 13 further including correlating collection of magnetic resonance image data which is representative of the center of k-space with the arrival time of the contrast agent in the region of interest.

16. The method of claim 13 wherein determining the arrival time of a magnetic resonance contrast agent in the region of interest includes using an arrival time of a test bolus.

17. The method of claim 13 further including correlating the suspension of the respiration of the patient with the collecting magnetic resonance image data.

18. The method of claim 17 wherein correlating the suspension of the respiration of the patient with the collecting magnetic resonance image data includes collecting a substantial portion of the image data which is representative of the center of k-space while the patient suspends respiration.

19. The method of claim 17 wherein collecting magnetic resonance image data further includes using a TR which is less than about 10 milliseconds, a TE which is less than about 7 milliseconds, and a flip angle which is between about 30°

and about 90°

.

20. The method of claim 13 further including imaging at least one renal artery of the patient by collecting image data which is representative of the center of k-space while the concentration of the contrast agent in the renal artery is greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

21. The method of claim 13 wherein collecting magnetic resonance image data further includes using a slice thickness which is less than about 4 millimeters and the image volume of the 3D pulse sequence includes at least one dimension which is at least about 25 centimeters.

22. The method of claim 13 wherein collecting magnetic resonance image data further includes collecting image data of the periphery of k-space while the concentration of the contrast agent in the artery is greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

23. The method of claim 13 wherein determining the arrival time of a magnetic resonance contrast agent in the region of interest includes estimating the arrival time based on the physical condition of the patient or the location of the artery in the patient.

24. The method of claim 13 further including instructing the patient to suspend respiration immediately before collecting the magnetic resonance image data which is representative of the center of k-space.

25. A method of imaging an artery of a patient using a magnetic resonance imaging system, the method comprising:

calculating an arrival time of the contrast agent in the region of interest;

injecting a magnetic resonance contrast agent to the patient;

correlating collection of magnetic resonance image data which is representative of the center of k-space with the injection of the magnetic resonance contrast agent using the arrival time of the contrast agent in the region of interest;

collecting magnetic resonance image, including the image data which is representative of the center of k-space, using a 3D pulse sequence, wherein at least a portion of the image data is collected while the concentration of the contrast in the artery is greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

26. The method of claim 25 wherein calculating the arrival time of the contrast agent in a region of interest includes using a test bolus.

27. The method of claim 25 wherein collecting magnetic resonance image data includes collecting a substantial portion of the image data while the patient suspends respiration.

28. The method of claim 25 wherein collecting magnetic resonance image data further includes using a TR which is less than about 10 milliseconds.

29. The method of claim 25 further including imaging at least one renal artery of the patient by collecting magnetic resonance image data using a 3D pulse sequence, the image data being collected while the concentration of the contrast agent in the renal artery is greater than a concentration of the contrast agent in veins and background tissue adjacent to the renal artery.

30. The method of claim 25 wherein calculating the arrival time of a magnetic resonance contrast agent in the region of interest includes calculating the arrival time based on the physical condition or age of the patient.

31. The method of claim 25 further including instructing the patient to suspend respiration before collecting the magnetic resonance image data which is representative of the center of k-space.

32. The method of claim 25 wherein collecting magnetic resonance image data includes collecting image data which is representative of the periphery of k-space immediately after collecting image data which is representative of the center of k-space.

33. The method of claim 25 further including instructing the patient to suspend respiration immediately before collecting the magnetic resonance image data which is representative of the center of k-space.