Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
First Claim
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1. A compound comprising at least one pharmaceutically acceptable anion and a cation represented by the following formula:
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Abstract
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of ΔΨm, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
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Citations
20 Claims
- 1. A compound comprising at least one pharmaceutically acceptable anion and a cation represented by the following formula:
- 3. A compound comprising at least one pharmaceutically acceptable anion and a cation represented by the following formula:
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8. A compound which selected from the group consisting of:
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18F-4-fluorobenzyl-triphenylphosphonium; 18F-2-fluorobenzyl-triphenylphosphonium;
or18F-3-fluorobenzyl-triphenylphosphonium.
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9. A compound selected from the group consisting of
18F-2-fluoroethyl-triphenylphosphonium; -
18F-2-fluoroethyl-tri-ortho-tolylphosphonium; 18F-2-fluoroethyl-tri-meta-tolylphosphonium; 18F-2-fluoroethyl-tri-para-tolylphosphonium; 18F-3-fluoropropyl-triphenylphosphonium; 18F-3-fluoropropyl-tri-ortho-tolylphosphonium; 18F-3-fluoropropyl-tri-meta-tolylphosphonium; 18F-3-fluoropropyl-tri-para-tolylphosphonium; 18F-4-fluorobutyl-triphenylphosphonium; 18F-4-fluorobutyl-tri-ortho-tolylphosphonium; 18F-4-fluorobutyl-tri-meta-tolylphosphonium; 18F-4-fluorobutyl-tri-para-tolylphosphonium; 18F-2-fluorobenzyl-tri-ortho-tolylphosphonium; 18F-2-fluorobenzyl-tri-meta-tolylphosphonium; 18F-2-fluorobenzyl-tri-para-tolylphosphonium; 18F-3-fluorobenzyl-tri-ortho-tolylphosphonium; 18F-3-fluorobenzyl-tri-meta-tolylphosphonium; 18F-3-fluorobenzyl-tri-para-tolylphosphonium; 18F-4-fluorobenzyl-tri-ortho-tolylphosphonium; 18F-4-fluorobenzyl-tri-meta-tolylphosphonium; 18F-4-fluorobenzyl-tri-para-tolylphosphonium; 18F-3-fluoro-4-formyl-benzyl-triphenylphosphonium; 18F-3-fluoro-4-formyl-benzyl-tri-ortho-tolylphosponium; 18F-3-fluoro-4-formyl-benzyl-tri-meta-tolylphosphonium; 18F-3-fluoro-4-formyl-benzyl-tri-para-tolylphosphonium; (18F-4-fluorobenzyl)-(2-chloroethyl)-diphenylphosphonium; (18F-4-fluorobenzyl)-(3-chloropropyl)-diphenylphosphonium; (18F-4-fluorobenzyl)-(4-chlorobutyl)-diphenylphosphonium; (18F-4-fluorobenzyl)-(6-chloropentyl)-diphenylphosphonium; (18F-4-fluorobenzyl)-(5-chlorohexyl)-diphenylphosphonium; 18F-2-fluoroethyl-tri(4-pyridyl)phosphonium; 18F-3-fluoropropyl-tri(4-pyridyl)phosphonium; 18F-4-fluorobutyl-tri(4-pyridyl)phosphonium; 18F-2-fluorobenzyl-tri(4-pyridyl)phosphonium; 18F-3-fluorobenzyl-tri(4-pyridyl)phosphonium; 18F-4-fluorobenzyl-tri(4-pyridyl)phosphonium;
or18F-3-fluoro-4-formyl-benzyl-tri(4-pyridyl)phosphonium.
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Specification