Solid wound healing formulations containing fibronectin
First Claim
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1. A method of producing a wound healing promoter delivery system comprising the steps ofa) preparing a concentrated solution of fibronectin adjusted to a pH of 8.0 to 11.6:
- b) preparing a solution of an alginate salt;
c) mixing the solution of step (a) and the solution of step (b) at a pH which is equal to or lower than the isoelectric point of fibronectin when fibronectin is positively charged to form a homogeneous mixture;
d) adding glacial acetic acid to achieve a final pH of 5.0;
e) freeze-drying the homogeneous mixture having a pH of 5.0 of step (c) to produce the solid wound healing formulation.
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Abstract
A concentrated solution of a wound healing promoter, in particular fibronectin, is used to develop solid wound dressings. The solid wound dressings containing fibronectin are easy to apply, easy to remove, and deliver fibronectin in a range of physiologically active dosages.
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2 Claims
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1. A method of producing a wound healing promoter delivery system comprising the steps of
a) preparing a concentrated solution of fibronectin adjusted to a pH of 8.0 to 11.6: -
b) preparing a solution of an alginate salt; c) mixing the solution of step (a) and the solution of step (b) at a pH which is equal to or lower than the isoelectric point of fibronectin when fibronectin is positively charged to form a homogeneous mixture; d) adding glacial acetic acid to achieve a final pH of 5.0; e) freeze-drying the homogeneous mixture having a pH of 5.0 of step (c) to produce the solid wound healing formulation. - View Dependent Claims (2)
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Current AssigneeAndre Beaulieu
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Original AssigneeAndre Beaulieu
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InventorsBeaulieu, Andre, Paquin, Robert, Lariviere, Benoit
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Primary Examiner(s)KIM, VICKIE Y
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Application NumberUS10/049,992Time in Patent Office2,227 DaysField of Search424/78.06, 424/426, 514/8US Class Current424/78.06CPC Class CodesA61K 31/74 Synthetic polymeric materialsA61K 38/39 Connective tissue peptides,...
