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Methods of culturing embryonic stem cells and controlled differentiation

  • US 7,112,437 B2
  • Filed: 06/20/2001
  • Issued: 09/26/2006
  • Est. Priority Date: 06/20/2000
  • Status: Expired due to Term
First Claim
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1. A method of producing a human neural progenitor cell from a human ES cell, said method comprising:

  • obtaining a source of an undifferentiated human ES cell; and

    culturing the ES cell in the presence of an antagonist of a BMP mediated default pathway of extra embryonic endoderm differentiation to differentiate the ES cell to a progenitor cell, wherein said progenitor cell lacks at least one marker of said undifferentiated ES cell; and

    culturing the progenitor cell in a neural progenitor cell culture medium to obtain a neural progenitor cell.

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