Retentate chromatography and protein chip arrays with applications in biology and medicine
First Claim
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1. A probe used in laser desorption/ionization mass spectrometry comprising:
- a) a metal substrate in the shape of a plate or a strip having a flat surface, wherein the flat surface of the substrate is coated with silicon oxide or titanium oxide;
b) a plurality of addressable locations on the flat surface of the substrate, wherein each addressable location comprises an adsorbent covalently attached to the coated surface,wherein the probe is inserted into a laser desorption/ionization mass spectrometer.
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Abstract
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
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Citations
16 Claims
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1. A probe used in laser desorption/ionization mass spectrometry comprising:
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a) a metal substrate in the shape of a plate or a strip having a flat surface, wherein the flat surface of the substrate is coated with silicon oxide or titanium oxide; b) a plurality of addressable locations on the flat surface of the substrate, wherein each addressable location comprises an adsorbent covalently attached to the coated surface, wherein the probe is inserted into a laser desorption/ionization mass spectrometer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification