Tissue biopsy and processing device

• US 7,115,100 B2
• Filed: 11/15/2002
• Issued: 10/03/2006
• Est. Priority Date: 11/15/2002
• Status: Expired due to Term

• Current Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Binette, Francois, Hwang, Julia, McRury, Ian D.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): FOREMAN, JONATHAN M
• Application Number:
  US10/298,091
• Publication Number:
  US 20040097829A1
• Time in Patent Office: 1,418 Days
• Field of Search: 600562-567, 606/167
• US Class Current: 600/562
• CPC Class Codes: A61B 10/025 for taking bone, bone marrow or cartilage samples
• CPC Class Codes: A61B 10/0266 means for severing sample
• CPC Class Codes: A61B 10/0283 with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe A61B10/025, A61B10/0266 take precedence
• CPC Class Codes: A61B 17/3203 Fluid jet cutting instruments
• CPC Class Codes: A61B 2017/00685 Archimedes screw
• CPC Class Codes: A61B 2017/00969 used for transplantation
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61M 1/79 Filters for solid matter specially adapted for dental use A61C17/065

Abstract

A tissue biopsy and processing device for capturing and processing a tissue sample is provided. In general, the device includes a biopsy member adapted to remove a tissue sample from a patient'"'"'s body, and a processing apparatus adapted to receive the tissue sample from the biopsy device, and to dissociate and mince the tissue sample in preparation for further use. The processing apparatus can include a tissue reducing chamber in communication with and adapted to receive the tissue sample from the biopsy member, and a tissue processing element associated with the tissue reducing chamber that is effective to dissociate the tissue sample retained within the tissue reducing chamber.

Claims

1. A tissue biopsy and processing device, comprising:

a biopsy member adapted to remove a tissue sample from a patient;

a processing apparatus having a tissue reducing chamber in communication with and adapted to receive the tissue sample from the biopsy member, and a tissue processing element associated with the tissue reducing chamber that is effective to dissociate the tissue sample retained within the tissue reducing chamber;

a tissue retaining element located within the tissue reducing chamber for holding the tissue sample while the tissue processing element dissociates the tissue sample; and

a bioimplantable tissue scaffold in communication with the processing apparatus and effective to receive the dissociated tissue sample from the tissue processing element.

2. The device of claim 1, wherein the device is in the form of an elongate member having a proximal end, a distal end, and an inner lumen extending therebetween, the biopsy member being formed on the distal end of the elongate member and the tissue reducing chamber being formed within the inner lumen proximal to the distal end of the elongate member.

3. The device of claim 2, wherein the biopsy member is effective to retrieve and convey a tissue sample to the tissue reducing chamber.

4. The device of claim 3, wherein the tissue processing element is disposed within the tissue reducing chamber.

5. The device of claim 1, wherein the biopsy member is selected from the group consisting a suction member, a cutting member, a burr, a shaver, a curette, a rongeur, a high pressure fluid jet, a grasping member, a needle, and combinations thereof.

6. The device of claim 1, wherein the tissue reducing chamber includes an isolation member effective to prevent foreign substances from entering the reducing chamber after a tissue sample is disposed within the chamber.

7. The device of claim 6, wherein the isolation member comprises a hinged flap movable between an open position, in which the chamber can receive a tissue sample, and a closed position, in which the chamber is sealed.

8. The device of claim 1, wherein the tissue processing element comprises a high pressure fluid jet.

9. The device of claim 1, wherein the tissue retaining element comprises a filter having pores sufficient to retain the tissue sample.

10. The device of claim 1, wherein the tissue processing element comprises a mechanical cutting element.

11. The device of claim 10, wherein the mechanical cutting element is selected from the group consisting of an auger, a rongeur, a curette, an awl, a reamer, a corer, a blade, a grinding member, a grating member, and combinations thereof.

12. The device of claim 1, wherein the tissue retaining element comprises a siphoning member in communication with the tissue reducing chamber that is effective to receive a tissue sample after the tissue sample is processed by the tissue processing element and to remove excess fluid from the tissue sample.

13. The device of claim 2, wherein the tissue processing element is slidably disposed within the tissue reducing chamber.

14. A method for preparing a tissue slurry, comprising:

providing a device having a biopsy member for retrieving a tissue sample from a patient, and a processing element disposed within a tissue reducing chamber in communication with the biopsy member and effective to dissociate and mince the tissue sample;

removing a tissue sample from a patient'"'"'s body using the biopsy member, the tissue sample being collected in the tissue reducing chamber;

processing the tissue sample collected in the tissue reducing chamber with the processing element to dissociate and mince the tissue; and

collecting the dissociated and minced tissue on a biological implant located proximal to the tissue reducing chamber to prepare the biological implant for subsequent implantation.

15. The method of claim 14, wherein the biological implant comprises a tissue scaffold.

16. The method of claim 15, wherein the dissociated and minced tissue sample is disposed within a fluid, and wherein the tissue scaffold is fluid permeable to enable the fluid to flow therethrough, thereby separating the dissociated and minced tissue from the fluid.

17. The method of claim 14, wherein the particle size of the dissociated and minced tissue fragments is in the range of about 0.1 mm³ to 3 mm³.

18. The method of claim 14, wherein the particle size of the dissociated and minced tissue fragments is less than about 1 mm³.

19. The method of claim 14, wherein the dissociated and minced tissue is in the form of an amorphous slurry.